Jørgensen H L, Hassager C
Center for Clinical and Basic Research, Ballerup, Denmark.
Bone. 1997 Jul;21(1):109-12. doi: 10.1016/s8756-3282(97)00073-2.
Quantitative ultrasound (QUS) bone measurement is a promising, relatively new technique for the diagnosis of osteoporosis. Contrary to the more established method of bone densitometry (measurement of bone mineral density, BMD, e.g., using dual X-ray absorptiometry, DEXA), QUS does not employ ionizing radiation. It has, however, been a problem to achieve sufficient reproducibility of the QUS measurements. The aim of this study is to evaluate the possible advantages of measuring broadband ultrasound attenuation (BUA) at a region of interest (ROI) instead of at a fixed position, in terms of in vivo precision and correlation to hip bone mineral density. BUA was measured in 27 premenopausal women, 28 postmenopausal women, an 22 men on the DTU-one. Using high resolution images, a ROI is defined in the posterior part of the os calcis as an area with a local minimum of attenuation and a fixed position within the os calcis is defined relative to the water bath. All BUA measurements were performed twice. BMD at the hip was measured on the QDR-2000. The mean BUA values were significantly different between pre- and postmenopausal women, p = 0.0001 for both the ROI (BUAROI) and the fixed position (BUAFIX). The ROI was found in all subjects and was readily reproducible. The precision at the ROI: 1.20 CV% (95% CI: 1.01-1.29 CV%) was significantly better than at the fixed position: 3.87 CV% (95% CI: 3.23-4.48 CV%). BUAROI (r = 0.64) correlated significantly better than BUAFIX (r = 0.35) with HIP BMD. In conclusion, the use of an imaging technique enables BUA measurements to be performed at a ROI. The precision of BUA at the ROI is significantly better than at the fixed position. BUA measured at the ROI correlates better with HIP BMD than BUA measured at the fixed position.
定量超声（QUS）骨测量是一种很有前景的、相对较新的骨质疏松症诊断技术。与更成熟的骨密度测量方法（测量骨矿物质密度，BMD，例如使用双能X线吸收法，DEXA）不同，QUS不使用电离辐射。然而，实现QUS测量足够的可重复性一直是个问题。本研究的目的是评估在感兴趣区域（ROI）而非固定位置测量宽带超声衰减（BUA）在体内精度和与髋部骨矿物质密度相关性方面的潜在优势。在DTU-one上对27名绝经前女性、28名绝经后女性和22名男性进行了BUA测量。使用高分辨率图像，在跟骨后部定义一个ROI，作为衰减局部最小值的区域，并相对于水浴在跟骨内定义一个固定位置。所有BUA测量均进行两次。在QDR-2000上测量髋部的BMD。绝经前和绝经后女性的平均BUA值有显著差异，ROI（BUAROI）和固定位置（BUAFIX）的p值均为0.0001。在所有受试者中均发现了ROI，并且易于重复。ROI处的精度：1.20 CV%（95%CI：1.01 - 1.29 CV%）明显优于固定位置：3.87 CV%（95%CI：3.23 - 4.48 CV%）。BUAROI（r = 0.64）与髋部BMD的相关性明显优于BUAFIX（r = 0.35）。总之，使用成像技术能够在ROI处进行BUA测量。ROI处BUA的精度明显优于固定位置。在ROI处测量的BUA与髋部BMD的相关性优于在固定位置测量的BUA。
