Chen K S, Wu Y C, Teng C M, Ko F N, Wu T S
Ta-Jen Pharmaceutical Junior College, Taiwan, Republic of China.
J Nat Prod. 1997 Jun;60(6):645-7. doi: 10.1021/np9700735.
Using antiplatelet aggregation as a guide to fractionation, seven aporphines, actinodaphnine (1), N-methylactinodaphnine (2), launobine (3), dicentrine (4), O-methylbulbocapnine (5), hernovine (7), and bulbocapnine (9), and two oxoaporphines, dicentrinone (6) and liriodenine (8), were isolated from the stems of Illigera luzonensis. Among them, compounds 2, 4, 5, 8, and 9 were isolated for the first time from this species. Moreover, compounds 1-5, and 8 showed significant antiplatelet aggregation and compounds 1 and 6 exhibited significant vasorelaxant activities, respectively.
以抗血小板聚集为分离导向，从吕宋青藤的茎中分离得到了七种阿朴啡类生物碱，即木姜叶柯碱（1）、N - 甲基木姜叶柯碱（2）、劳诺宾碱（3）、双苄基异喹啉碱（4）、O - 甲基紫堇灵（5）、赫诺文碱（7）和紫堇灵（9），以及两种氧化阿朴啡类生物碱，双苄基异喹啉酮（6）和莲叶桐碱（8）。其中，化合物2、4、5、8和9首次从该物种中分离得到。此外，化合物1 - 5和8显示出显著的抗血小板聚集活性，化合物1和6分别表现出显著的血管舒张活性。
