Hunger R E, Hristic M, Mueller C, Kappeler A, Altermatt H J
Department of Pathology, University of Bern, Switzerland.
J Clin Pathol. 1997 Apr;50(4):310-3. doi: 10.1136/jcp.50.4.310.
The contribution of a cellular immune response to tissue destruction in sclerosing lymphocytic lobulitis of the breast is not well understood. In this study, comparison of one case with two age matched control cases showed an increased frequency of activated perforin mRNA expressing cells at the site of tissue destruction in lobulitis. Along with the detection of tumour necrosis factor alpha (TNF alpha) mRNA expressing cells in the infiltrates, the striking association of perforin expressing activated cytotoxic cells with remaining gland parenchyma and the high level of perforin mRNA suggests activation of cytotoxic cells in situ. These findings are evidence that cell mediated cytotoxicity plays a significant role in the destruction of mammary gland tissue in sclerosing lymphocytic lobulitis.
细胞免疫反应在乳腺硬化性淋巴细胞性小叶炎的组织破坏中所起的作用尚未得到充分了解。在本研究中，将1例病例与2例年龄匹配的对照病例进行比较，结果显示小叶炎组织破坏部位表达穿孔素mRNA的活化细胞频率增加。除了在浸润物中检测到表达肿瘤坏死因子α（TNFα）mRNA的细胞外，表达穿孔素的活化细胞毒性细胞与剩余腺实质的显著关联以及穿孔素mRNA的高水平表明细胞毒性细胞在原位被激活。这些发现证明细胞介导的细胞毒性在乳腺硬化性淋巴细胞性小叶炎的乳腺组织破坏中起重要作用。
