vd Berg G M, Lillieborg S, Stolz E
Department of Dermatovenereology, University Hospital Rotterdam/Dijkzigt, The Netherlands.
Genitourin Med. 1992 Jun;68(3):162-5. doi: 10.1136/sti.68.3.162.
To compare analgesic efficacy and pain caused by administration of lidocaine/prilocaine cream (EMLA(R)) versus xylocaine 1% local infiltration for punch biopsy and electrocoagulation of genital warts in men.
Open randomised comparative parallel-group study.
Department of Dermatovenereology, University Hospital Rotterdam/Dijkzigt, the Netherlands.
63 males with warts on the genital mucosa and/or perianal area.
EMLA(R) cream (2.5-5 g) was applied during 13-45 minutes before surgery. Xylocaine 1% (0.1-4 ml) was infiltrated 0.5-4 minutes before surgery. Pain during administration and surgery was assessed by the patient on a verbal rating scale and on a visual analogue scale.
EMLA(R) application was painless in all patients (n = 31) whereas xylocaine infiltration was slightly painful in 17/29 patients and moderately painful in 10/29 patients. EMLA(R) analgesia was satisfactory for 94% of biopsies and 62% of electrocoagulations. Xylocaine infiltration was satisfactory in all procedures.
EMLA(R) application on the male genital mucosa is painless but it has a lower analgesic efficacy than xylocaine infiltration. However EMLA is a useful anaesthetic for taking biopsies in this area and may be used as premedication for local infiltration.
比较利多卡因/丙胺卡因乳膏（复方利多卡因乳膏）与1%利多卡因局部浸润用于男性尖锐湿疣打孔活检和电凝治疗时的镇痛效果及引起的疼痛。
开放性随机对照平行组研究。
荷兰鹿特丹大学医院/迪克济希特皮肤病与性病科。
63名男性，其生殖器黏膜和/或肛周区域有疣。
手术前13 - 45分钟涂抹复方利多卡因乳膏（2.5 - 5 g）。手术前0.5 - 4分钟注射1%利多卡因（0.1 - 4 ml）。患者通过语言评分量表和视觉模拟量表评估给药和手术过程中的疼痛。
所有患者（n = 31）涂抹复方利多卡因乳膏时均无痛，而29例患者中17例利多卡因浸润时稍有疼痛，10例中度疼痛。复方利多卡因乳膏对94%的活检和62%的电凝治疗镇痛效果满意。利多卡因浸润在所有操作中效果均满意。
在男性生殖器黏膜上涂抹复方利多卡因乳膏无痛，但镇痛效果低于利多卡因浸润。然而，复方利多卡因乳膏是该区域活检的一种有用麻醉剂，可作为局部浸润的术前用药。
