Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Environ Health Perspect. 2013 Feb;121(2):153-61. doi: 10.1289/ehp.1205248. Epub 2012 Nov 5.
Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies.
We prospectively examined plasma POP concentrations in relation to incident T2D and summarized existing evidence in a meta-analysis.
Plasma polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) concentrations were measured in 1,095 women who were free of diabetes at blood draw in 1989-1990 and participated in two case-control studies in the Nurses' Health Study. We identified 48 incident T2D cases through 30 June 2008. We conducted a literature search in PubMed and EMBASE through December 2011 to identify prospective studies on POPs in relation to diabetes. We used a fixed-effects model to summarize results.
After multivariable adjustment, plasma HCB concentration was positively associated with incident T2D [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing extreme tertiles]. Other POPs were not significantly associated with diabetes. After pooling our results with those of six published prospective studies that included 842 diabetes cases in total, we found that HCB and total PCBs both were associated with diabetes: the pooled ORs were 2.00 (95% CI: 1.13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) and 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for HCB and total PCBs, respectively.
These findings support an association between POP exposure and the risk of T2D.
关于持久性有机污染物（POPs）与 2 型糖尿病（T2D）风险的前瞻性数据有限，并且个别 POPs 的研究结果在不同研究中并不完全一致。
我们前瞻性地研究了血浆中 POP 浓度与 T2D 发病的关系，并通过荟萃分析总结了现有证据。
在 1989-1990 年采血时无糖尿病的 1095 名女性中测量了血浆多氯联苯（PCBs）、滴滴涕（DDT）、二氯二苯二氯乙烯（DDE）和六氯苯（HCB）的浓度，并参加了两项护士健康研究中的病例对照研究。截至 2008 年 6 月 30 日，我们确定了 48 例新发 T2D 病例。我们在 PubMed 和 EMBASE 中进行了文献检索，检索时间截至 2011 年 12 月，以确定关于 POPs 与糖尿病关系的前瞻性研究。我们使用固定效应模型来总结结果。
经过多变量调整后，血浆 HCB 浓度与 T2D 发病呈正相关[极端三分位组比较的汇总优势比（OR）为 3.59（95%CI：1.49，8.64，ptrend = 0.003）]。其他 POPs 与糖尿病无显著相关性。将我们的结果与包括 842 例糖尿病病例在内的 6 项已发表的前瞻性研究的结果进行汇总后，我们发现 HCB 和总 PCB 均与糖尿病有关：汇总 OR 分别为 2.00（95%CI：1.13，3.53；I2 = 21.4%，pheterogeneity = 0.28）和 1.70（95%CI：1.28，2.27；I2 = 16.3%，pheterogeneity = 0.30）。
这些发现支持 POP 暴露与 T2D 风险之间存在关联。
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