Shimada-Hiratsuka M, Fukayama M, Hayashi Y, Ushijima T, Suzuki M, Hishima T, Funata N, Koike M, Watanabe T
Department of Diagnostic Pathology, Kanto Teishin Hospital, Tokyo, Japan.
Cancer. 1997 Jul 15;80(2):292-303. doi: 10.1002/(sici)1097-0142(19970715)80:2<292::aid-cncr18>3.0.co;2-p.
Gastric T-cell lymphomas are rare, and their incidence and viral status have not yet been fully clarified.
Sixty-seven cases of surgically resected gastric lymphomas from city hospitals in Tokyo were evaluated. The surface phenotype was determined by immunohistochemistry, gene rearrangement by Southern blot hybridization, association with Epstein-Barr virus (EBV) by EBV-encoded small RNAs in situ hybridization, and the presence of human T-cell lymphotropic virus type 1 (HTLV-1) by serology, Southern blot hybridization, and polymerase chain reaction analysis.
Five of the 67 cases were T-cell lymphoma (7%): 3 cases were HTLV-1 negative (-) and 2 were HTLV-1 positive (+). Systemic eosinophilia was observed in the three HTLV-1(-) gastric lymphomas. Neoplastic cells were morphologically similar in both groups, but a granulomatous reaction with marked eosinophilia was observed only in the two cases of HTLV-1(-) lymphoma. They also had characteristics of natural killer (NK) cell-like T-cell lymphoma, expressing NK markers and TCRgamma gene rearrangement. Positivity with HML-1 (specific for intestinal epithelial T-cells lymphoma was observed in one HTLV-1(+) lymphoma. The EBV gene was detected in only one case of B-cell lymphoma but not in any case of T-cell lymphoma.
Gastric T-cell lymphoma occurs in 7% of gastric lymphomas in Japan and is comprised of HTLV-1-related lymphomas and lymphomas unrelated to HTLV-1, including NK cell-like lymphomas with eosinophilia.
胃T细胞淋巴瘤较为罕见，其发病率及病毒状态尚未完全明确。
对东京市立医院手术切除的67例胃淋巴瘤病例进行评估。通过免疫组织化学确定表面表型，通过Southern印迹杂交检测基因重排，通过EBV编码小RNA原位杂交检测与EB病毒（EBV）的关联，通过血清学、Southern印迹杂交及聚合酶链反应分析检测人类嗜T细胞病毒1型（HTLV-1）的存在情况。
67例病例中有5例为T细胞淋巴瘤（7%）：3例HTLV-1阴性（-），2例HTLV-1阳性（+）。3例HTLV-1（-）胃淋巴瘤中观察到全身嗜酸性粒细胞增多。两组肿瘤细胞形态相似，但仅在2例HTLV-1（-）淋巴瘤中观察到伴有明显嗜酸性粒细胞增多的肉芽肿反应。它们还具有自然杀伤（NK）细胞样T细胞淋巴瘤的特征，表达NK标志物及TCRγ基因重排。在1例HTLV-1（+）淋巴瘤中观察到HML-1阳性（对肠道上皮T细胞淋巴瘤具有特异性）。仅在1例B细胞淋巴瘤中检测到EBV基因，而在任何T细胞淋巴瘤病例中均未检测到。
在日本，胃T细胞淋巴瘤占胃淋巴瘤的7%，由HTLV-1相关淋巴瘤及与HTLV-1无关的淋巴瘤组成，包括伴有嗜酸性粒细胞增多的NK细胞样淋巴瘤。
