耳源性脑脓肿的细菌学研究：甲硝唑的化疗作用
Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole.
作者信息
Ingham H R, Slekon J B, Roxby C M
出版信息
Br Med J. 1977 Oct 15;2(6093):991-3. doi: 10.1136/bmj.2.6093.991.
Abstract
In nine consecutive patients with otogenic cerebral abscesses a mixed growth of aerobic and obligate anaerobic bacteria was isolated from the pus in five patients, and in the remaining four obligate anaerobes were the sole isolates. The commonest obligate anaerobe isolated was Bacteroides fragilis, which was present in all but one patient. The patients were all treated with metronidazole for the anaerobic organisms and with appropriate chemotherapy against the aerobic organisms isolated. All the patients recovered and only one was left with a neurological deficit. As otogenic cerebral abscesses constitute a major proportion of all cerebral abscesses, the use of metronidazole against obligate anaerobic bacteria, which tend to dominate in such abscesses, should reduce the high mortality from this condition.
摘要
在9例连续性耳源性脑脓肿患者中，5例患者的脓液中分离出需氧菌和专性厌氧菌的混合菌，其余4例仅分离出专性厌氧菌。分离出的最常见专性厌氧菌是脆弱拟杆菌，除1例患者外，其他患者均有该菌。所有患者均接受甲硝唑治疗厌氧菌，并针对分离出的需氧菌进行适当的化疗。所有患者均康复，仅1例遗留神经功能缺损。由于耳源性脑脓肿在所有脑脓肿中占很大比例，使用甲硝唑治疗在此类脓肿中占主导的专性厌氧菌，应可降低该病的高死亡率。
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