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女性的牛奶、膳食钙与骨折:一项为期12年的前瞻性研究。

Milk, dietary calcium, and bone fractures in women: a 12-year prospective study.

作者信息

Feskanich D, Willett W C, Stampfer M J, Colditz G A

机构信息

Channing Laboratory, Boston, Mass. 02115, USA.

出版信息

Am J Public Health. 1997 Jun;87(6):992-7. doi: 10.2105/ajph.87.6.992.

Abstract

OBJECTIVES

This study examined whether higher intakes of milk and other calcium-rich foods during adult years can reduce the risk of osteoporotic fractures.

METHODS

This was a 12-year prospective study among 77761 women, aged 34 through 59 years in 1980, who had never used calcium supplements. Dietary intake was assessed with a food-frequency questionnaire in 1980, 1984, and 1986. Fractures of the proximal femur (n = 133) and distal radius (n = 1046) from low or moderate trauma were self-reported on biennial questionnaires.

RESULTS

We found no evidence that higher intakes of milk or calcium from food sources reduce fracture incidence. Women who drank two or more glasses of milk per day had relative risks of 1.45 for hip fracture (95% confidence interval [CI] = 0.87, 2.43) and 1.05 for forearm fracture (95% CI = 0.88, 1.25) when compared with women consuming one glass or less per week. Likewise, higher intakes of total dietary calcium or calcium from dairy foods were not associated with decreased risk of hip or forearm fracture.

CONCLUSIONS

These data do not support the hypothesis that higher consumption of milk or other food sources of calcium by adult women protects against hip or forearm fractures.

摘要

目的

本研究探讨成年期摄入更多牛奶及其他富含钙的食物是否可降低骨质疏松性骨折的风险。

方法

这是一项针对77761名女性的为期12年的前瞻性研究,这些女性在1980年年龄为34至59岁,且从未使用过钙补充剂。在1980年、1984年和1986年通过食物频率问卷评估饮食摄入量。通过两年一次的问卷调查自报低或中度创伤导致的股骨近端骨折(n = 133)和桡骨远端骨折(n = 1046)情况。

结果

我们没有发现证据表明从食物来源摄入更多牛奶或钙可降低骨折发生率。与每周饮用一杯或更少牛奶的女性相比,每天饮用两杯或更多杯牛奶的女性髋部骨折的相对风险为1.45(95%置信区间[CI] = 0.87, 2.43),前臂骨折的相对风险为1.05(95% CI = 0.88, 1.25)。同样,总膳食钙或来自乳制品的钙摄入量较高与髋部或前臂骨折风险降低无关。

结论

这些数据不支持成年女性摄入更多牛奶或其他钙食物来源可预防髋部或前臂骨折这一假设。

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本文引用的文献

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Protein consumption and bone fractures in women.女性蛋白质摄入量与骨折情况
Am J Epidemiol. 1996 Mar 1;143(5):472-9. doi: 10.1093/oxfordjournals.aje.a008767.

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