Asrani S, Zeimer R, Goldberg M F, Zou S
Johns Hopkins University School of Medicine, Wilmer Ophthalmological Institute, Baltimore, Maryland 21287-9131, USA.
Ophthalmology. 1997 Jul;104(7):1145-51. doi: 10.1016/s0161-6420(97)30170-5.
The authors have further developed their method of retinal thickness analysis to rapidly generate multiple optical cross sections of the retina and provide thickness maps at the posterior pole. The potential use of this method was evaluated in a number of macular disorders.
A commercial prototype of the scanning retinal thickness analyzer was used to examine patients with a variety of macular diseases. A laser slit beam was projected on the retina and scanned across a 2- X 2-mm retinal area in 200 to 400 msec. The images of the intersection of the laser slit beam with the retina were recorded digitally and used for visualization of disease. Nine scans were combined, and an operator-free algorithm generated a three-dimensional thickness map at the posterior pole.
Cysts could be visualized in macular edema associated with diabetes mellitus and with retinal vein occlusion. The retinal thickness map quantitated the location, extent, and height of the edema. In serous detachment, the extent and the height of the retinal pigment epithelial elevation could be documented. In cases of suspected macular holes and pseudoholes, the diagnosis was considered more reliable than with conventional biomicroscopy. The extent of epiretinal membranes, the sites of adherence, and associated intraretinal cystic changes were identified. In glaucoma, the anatomic course of localized loss of neuronal retinal tissue could be traced.
Scanning retinal thickness analysis provided multiple optical cross sections of the retina and yielded information useful in the diagnosis and monitoring of macular diseases. The three-dimensional thickness map provided quantitative information that may be useful for clinical management.
作者进一步改进了他们的视网膜厚度分析方法，以快速生成视网膜的多个光学横截面，并提供后极部的厚度图。在多种黄斑疾病中评估了该方法的潜在用途。
使用扫描视网膜厚度分析仪的商业原型检查患有各种黄斑疾病的患者。激光裂隙光束投射到视网膜上，并在200至400毫秒内扫描2×2毫米的视网膜区域。激光裂隙光束与视网膜交叉处的图像进行数字记录，并用于疾病可视化。将九次扫描合并，一种无需操作员的算法在后极部生成三维厚度图。
在与糖尿病和视网膜静脉阻塞相关的黄斑水肿中可观察到囊肿。视网膜厚度图可对水肿的位置、范围和高度进行定量。在浆液性脱离中，可记录视网膜色素上皮隆起的范围和高度。在疑似黄斑裂孔和假性裂孔的病例中，诊断被认为比传统生物显微镜检查更可靠。可识别视网膜前膜的范围、附着部位以及相关的视网膜内囊性改变。在青光眼中，可追踪视网膜神经组织局部丢失的解剖过程。
扫描视网膜厚度分析提供了视网膜的多个光学横截面，并产生了有助于黄斑疾病诊断和监测的信息。三维厚度图提供了可能对临床管理有用的定量信息。
