Suzuma K, Kita M, Yamana T, Ozaki S, Takagi H, Kiryu J, Ogura Y
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan.
Am J Ophthalmol. 1998 Sep;126(3):409-16. doi: 10.1016/s0002-9394(98)00096-8.
To evaluate the retinal thickness analyzer, a new image analyzer involving laser-slit biomicroscopy, for quantitative assessment of retinal thickness in patients with macular edema secondary to retinal vein occlusion.
Fifty-eight patients (central retinal vein occlusion, 22 eyes; branch retinal vein occlusion, 36 eyes) with a clinical diagnosis of macular edema associated with retinal vein occlusion were evaluated. Retinal thickness analysis was performed with the retinal thickness analyzer. A green helium-neon laser slit directed into the eye was scanned to generate optical cross-sections of the retina. Images were analyzed by an automated software algorithm, and a detailed map of the retinal thickness was obtained.
Laser-slit images obtained with the retinal thickness analyzer in patients with macular edema associated with retinal vein occlusion disclosed intraretinal changes such as retinal edema, cystoid spaces, and hemorrhages. Linear regression analysis showed a significant relationship between the macular thickness in the central fovea and corrected visual acuity reported on a logMAR scale (P = .002, adjusted R2 = 0.40 in central retinal vein occlusion; P = .002, adjusted R2 = 0.34 in branch retinal vein occlusion).
We confirmed the capability of the retinal thickness analyzer to provide rapid and precise evaluation of macular thickening in patients with retinal vein occlusion.
评估视网膜厚度分析仪，一种涉及激光裂隙生物显微镜检查的新型图像分析仪，用于定量评估视网膜静脉阻塞继发黄斑水肿患者的视网膜厚度。
对58例临床诊断为与视网膜静脉阻塞相关的黄斑水肿患者（视网膜中央静脉阻塞22只眼；视网膜分支静脉阻塞36只眼）进行评估。使用视网膜厚度分析仪进行视网膜厚度分析。将一束绿色氦氖激光裂隙导入眼内进行扫描，以生成视网膜的光学横截面。图像由自动软件算法进行分析，从而获得详细的视网膜厚度图。
视网膜厚度分析仪在视网膜静脉阻塞继发黄斑水肿患者中获得的激光裂隙图像显示出视网膜内的变化，如视网膜水肿、囊样间隙和出血。线性回归分析显示，中央凹黄斑厚度与以logMAR视力表记录的矫正视力之间存在显著相关性（视网膜中央静脉阻塞中P = 0.002，调整后R2 = 0.40；视网膜分支静脉阻塞中P = 0.002，调整后R2 = 0.34）。
我们证实了视网膜厚度分析仪能够对视网膜静脉阻塞患者的黄斑增厚情况进行快速、精确的评估。
