Donnelly D
Department of Pharmacology, University of Leeds, UK.
FEBS Lett. 1997 Jun 16;409(3):431-6. doi: 10.1016/s0014-5793(97)00546-2.
The members of the secretin receptor family of G-protein-coupled receptors share no significant sequence similarity to the more familiar rhodopsin-like family. However, multiple sequence alignment analysis reveals seven hydrophobic regions with significant alpha-helical periodicity. Residues that are likely to be buried on the interior of the helical bundle and others that are likely to contact the lipid bilayer are identified. A predicted arrangement of the helical bundle is described in which, by comparison with the arrangement in the rhodopsin family, helices 2 and 7 are more buried within the bundle while helix 3 is more exposed to the lipid bilayer.
G蛋白偶联受体的促胰液素受体家族成员与更为人熟知的视紫红质样家族没有明显的序列相似性。然而，多序列比对分析揭示了七个具有显著α螺旋周期性的疏水区域。确定了可能埋在螺旋束内部的残基以及其他可能与脂质双层接触的残基。描述了螺旋束的预测排列，与视紫红质家族的排列相比，其中螺旋2和7更多地埋在束内，而螺旋3更多地暴露于脂质双层。
