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人胃癌和胃黏膜细胞增殖的体内有丝分裂动力学研究。

An in vivo stathmokinetic study of cell proliferation in human gastric carcinoma and gastric mucosa.

作者信息

Wright N A, Britton D C, Bone G, Appleton D R

出版信息

Cell Tissue Kinet. 1977 Sep;10(5):429-36. doi: 10.1111/j.1365-2184.1977.tb00861.x.

DOI:10.1111/j.1365-2184.1977.tb00861.x
PMID:922796
Abstract

Cell production rates were studied in a group of eleven patients with carcinoma of the stomach using an in vivo technique with vincristine. In normal pyloric mucosa estimates ranged from 8 to 15 cells/1000 cells/hr, and in the carcinomas from 3 to 24 cells/1000 cells/hr. Because of the very large variation in the data, comparison between individual tumours and normal mucosa is not regarded as being worth-while at this stage. The implications of these results for previous human in vivo stathmokinetic experiments are also discussed.

摘要

采用长春新碱体内技术,对一组11例胃癌患者的细胞生成率进行了研究。在正常幽门黏膜中,估计范围为每小时8至15个细胞/1000个细胞,而在癌组织中为每小时3至24个细胞/1000个细胞。由于数据变化非常大,现阶段认为在单个肿瘤与正常黏膜之间进行比较没有价值。还讨论了这些结果对先前人体体内静止期动力学实验的影响。

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引用本文的文献

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Cell proliferation in gastrointestinal mucosa.胃肠道黏膜中的细胞增殖
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2
Morphological studies on the long-term organ culture of colonic mucosa from normal and dimethylhydrazine treated rats.正常和经二甲基肼处理的大鼠结肠黏膜长期器官培养的形态学研究
Br J Cancer. 1984 Mar;49(3):281-90. doi: 10.1038/bjc.1984.45.
3
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Virchows Arch A Pathol Anat Histopathol. 1991;418(5):457-61. doi: 10.1007/BF01605933.
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Validation of organ culture in colonic adaptation to surgical manipulation.结肠对手术操作适应性中器官培养的验证
Gut. 1991 Sep;32(9):1027-30. doi: 10.1136/gut.32.9.1027.
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The stathmokinetic (mitostatic) effect of vincristine and vinblastine on human gliomas.长春新碱和长春碱对人胶质瘤的有丝分裂抑制效应。
Acta Neuropathol. 1979 Jun 15;47(1):21-5. doi: 10.1007/BF00698268.