Koss E, Weiner M, Ernesto C, Cohen-Mansfield J, Ferris S H, Grundman M, Schafer K, Sano M, Thal L J, Thomas R, Whitehouse P J
Case Western Reserve University, Department of Neurology, Cleveland, Ohio, USA.
Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S45-50. doi: 10.1097/00002093-199700112-00007.
As part of the effort of the NIA Alzheimer's disease cooperative study to develop improved instruments for quantifying effects in Alzheimer's disease (AD) clinical trials, patterns of agitated behaviors were evaluated with the Cohen-Mansfield Agitation Inventory (CMAI) in 241 AD patients and 64 healthy elderly controls with valid baseline assessment on the CMAI. The test-retest reliability of the CMAI over 1 month was good (r = 0.74 to 0.92). Physically and verbally nonaggressive behaviors were most often reported, whereas physically aggressive behaviors were rare. Frequency of agitated behaviors increased with dementia severity, especially for patients with a Mini-Mental Status Exam score of 0-4. Agitation tended to increase in the evening with dementia severity for the more impaired patients. Amount of agitation did increase after 12 months in all but controls and mildly demented patients. The CMAI shows promise for evaluating a unique aspect of behavior and may be useful in assessing the effects of cognitive enhancers and other types of psychotropic drugs on behavior in dementia patients.
作为美国国立衰老研究所阿尔茨海默病合作研究项目的一部分，旨在开发用于量化阿尔茨海默病（AD）临床试验效果的改进工具，研究者使用科恩-曼斯菲尔德激越量表（CMAI）对241例AD患者和64例健康老年对照者的激越行为模式进行了评估，这些患者和对照者在CMAI上有有效的基线评估。CMAI在1个月内的重测信度良好（r = 0.74至0.92）。身体和言语上的非攻击性行为报告最为常见，而身体攻击性行为则很少见。激越行为的频率随痴呆严重程度增加，尤其是对于简易精神状态检查评分为0 - 4分的患者。对于受损更严重的患者，激越倾向于在晚上随痴呆严重程度增加。除了对照者和轻度痴呆患者外，所有患者在12个月后激越程度确实增加了。CMAI在评估行为的一个独特方面显示出前景，可能有助于评估认知增强剂和其他类型精神药物对痴呆患者行为的影响。
