Hershow R C, Riester K A, Lew J, Quinn T C, Mofenson L M, Davenny K, Landesman S, Cotton D, Hanson I C, Hillyer G V, Tang H B, Thomas D L
University of Illinois at Chicago School of Public Health and College of Medicine, 60612, USA.
J Infect Dis. 1997 Aug;176(2):414-20. doi: 10.1086/514058.
To determine if hepatitis C virus (HCV) infection affects vertical transmission of human immunodeficiency virus (HIV), 487 HIV-infected pregnant women in the prospective, multicenter, Women and Infants Transmission Study had HCV antibody (anti-HCV by second-generation ELISA) and HCV RNA (by quantitative polymerase chain reaction) measured in peripartum maternal plasma; 161 (33%) were anti-HCV-positive. HIV vertical transmission occurred from 42 HCV-infected mothers (26.1%) versus 53 HCV-uninfected mothers (16.3%; odds radio [OR], 1.82; P = .01). In a logistic regression model that included maternal drug use, a potential confounder, HCV infection was marginally associated with perinatal HIV transmission (OR, 1.64; P = .05), whereas drug use was not. Women who transmitted HIV had higher levels of HCV RNA (median, 721,254 copies/mL) than those who did not (337,561 copies/mL; P = .01). Maternal HCV infection is associated with increased HIV vertical transmission. Further studies are needed to ascertain if HCV directly affects perinatal HIV transmission or is a marker for another factor, such as maternal drug use.
为确定丙型肝炎病毒（HCV）感染是否会影响人类免疫缺陷病毒（HIV）的垂直传播，在一项前瞻性、多中心的母婴传播研究中，对487名感染HIV的孕妇在围产期母血中检测了HCV抗体（采用第二代酶联免疫吸附测定法检测抗-HCV）和HCV RNA（采用定量聚合酶链反应检测）；其中161名（33%）抗-HCV呈阳性。42名感染HCV的母亲发生了HIV垂直传播（26.1%），而53名未感染HCV的母亲发生HIV垂直传播的比例为16.3%；比值比（OR）为1.82；P = 0.01。在一个包含母亲吸毒这一潜在混杂因素的逻辑回归模型中，HCV感染与围产期HIV传播存在微弱关联（OR，1.64；P = 0.05），而吸毒则无此关联。发生HIV传播的女性其HCV RNA水平（中位数为721,254拷贝/毫升）高于未发生传播的女性（337,561拷贝/毫升；P = 0.01）。母亲HCV感染与HIV垂直传播增加有关。需要进一步研究以确定HCV是直接影响围产期HIV传播还是其他因素（如母亲吸毒）的一个标志物。
