Papaevangelou V, Pollack H, Rochford G, Kokka R, Hou Z, Chernoff D, Hanna B, Krasinski K, Borkowsky W
Department of Pediatrics, New York University Medical Center-Bellevue Hospital Center, New York 10016, USA.
J Infect Dis. 1998 Oct;178(4):1047-52. doi: 10.1086/515668.
The transmission of perinatal hepatitis C virus (HCV) infection was studied retrospectively in 62 infants born to 54 HCV- and human immunodeficiency virus (HIV)-coinfected women enrolled in a prospective natural history study of HIV transmission. Infant HCV infection was assessed by nested RNA polymerase chain reaction. The overall rate of vertical HCV transmission was 16.4% (9/62). Most HCV-infected children did not develop antibodies to HCV. The rate of HCV infection was higher among HIV-infected infants (40%) than among HIV-uninfected infants (7.5%; odds ratio, 8.2; P = .009). This difference in transmission was not related to differences in maternal HCV load, as measured by branched DNA assay, or mode of delivery. Why HIV-infected infants of HCV- and HIV-coinfected women have significantly higher rates of perinatal HCV transmission remains to be elucidated. The rate of HCV transmission in HIV-uninfected infants of HCV- and HIV-coinfected women is similar to that reported for infants born to HIV-seronegative mothers.
对参与一项关于人类免疫缺陷病毒（HIV）传播的前瞻性自然史研究的54名丙型肝炎病毒（HCV）和HIV合并感染女性所生的62名婴儿进行了围产期HCV感染传播的回顾性研究。通过巢式RNA聚合酶链反应评估婴儿的HCV感染情况。垂直HCV传播的总体发生率为16.4%（9/62）。大多数HCV感染儿童未产生抗HCV抗体。HIV感染婴儿中的HCV感染率（40%）高于未感染HIV的婴儿（7.5%；优势比为8.2；P = 0.009）。这种传播差异与通过分支DNA检测法测定的母亲HCV载量差异或分娩方式无关。HCV和HIV合并感染女性的HIV感染婴儿围产期HCV传播率为何显著更高仍有待阐明。HCV和HIV合并感染女性的未感染HIV婴儿中的HCV传播率与HIV血清阴性母亲所生婴儿的报告传播率相似。
