Lowe M E
Washington University School of Medicine, Department of Pediatrics, St. Louis, Missouri 63110, USA.
Annu Rev Nutr. 1997;17:141-58. doi: 10.1146/annurev.nutr.17.1.141.
Dietary fats are essential for life and good health. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase. In the last few years, large advances have been made in describing the structure and lipolytic mechanism of human pancreatic triglyceride lipase and of colipase, another pancreatic protein that interacts with pancreatic triglyceride lipase and that is required for lipase activity in the duodenum. This review discusses the advances made in protein structure and in understanding the relationships of structure to function of pancreatic triglyceride lipase and colipase.
膳食脂肪对生命和健康至关重要。膳食脂肪的有效吸收依赖于胰脂肪酶的作用。在过去几年中，在描述人胰脂肪酶和辅脂酶（另一种与胰脂肪酶相互作用且是十二指肠中脂肪酶活性所必需的胰腺蛋白）的结构和脂解机制方面取得了重大进展。本综述讨论了在蛋白质结构以及理解胰脂肪酶和辅脂酶的结构与功能关系方面所取得的进展。
