Manganaro A M, Cross S E, Startzell J M
Department of Oral and Maxillofacial Surgery, Brooke Army Medical Center, Hospital Dental Clinic (Oral Surgery), Fort Sam Houston, Texas 78234-6200, USA.
Head Neck. 1997 Aug;19(5):436-9. doi: 10.1002/(sici)1097-0347(199708)19:5<436::aid-hed12>3.0.co;2-5.
Squamous cell carcinoma arising in a dentigerous cyst is extremely uncommon. The diagnosis of carcinoma arising in a dentigerous cyst requires microscopically that an area of benign cystic epithelium is observed to transition into squamous cell carcinoma. In the present case, the patient was diagnosed with squamous cell carcinoma of the neck with an unknown primary. The primary site was found to be the follicular space associated with the right mandibular third molar.
Light microscopic studies were performed to arrive at the final diagnosis.
Transition of the epithelial lining of the dentigerous cyst to squamous cell carcinoma was observed in multiple fields.
The present case demonstrates that odontogenic cysts have to be considered a possible source of metastatic disease.
牙源性囊肿中发生的鳞状细胞癌极为罕见。牙源性囊肿中癌的诊断在显微镜下要求观察到良性囊性上皮区域转变为鳞状细胞癌。在本病例中，患者被诊断为颈部鳞状细胞癌，原发部位不明。发现原发部位是与右下颌第三磨牙相关的滤泡间隙。
进行光镜研究以得出最终诊断。
在多个视野中观察到牙源性囊肿的上皮衬里转变为鳞状细胞癌。
本病例表明牙源性囊肿必须被视为转移性疾病的可能来源。
