Lin H C, Purohit R C, Powe T A
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522, USA.
Vet Surg. 1997 May-Jun;26(3):247-52. doi: 10.1111/j.1532-950x.1997.tb01494.x.
This study evaluates the clinical usefulness and anesthetic effect of propofol, and compares these effects with those of xylazine-ketamine-halothane anesthesia in sheep.
Prospective, randomized, clinical trial.
Fourteen healthy adult male sheep.
Sheep were randomly assigned to two different drug regimens: (1) Bolus injection of propofol (3 mg/kg, intravenously [i.v.]) followed by continuous intravenous infusion and (2) xylazine (0.11 mg/kg, i.v.) and ketamine (2.2 mg/kg, i.v.) for induction followed by halothane anesthesia. Heart rate, respiratory rate, and arterial blood pressures were monitored during anesthesia. Venous blood samples were collected for blood gas analysis. Quality of induction and recovery were also recorded.
The average dose of propofol used to induce and maintain anesthesia was 6.63 +/- 2.06 mg/kg and 29.3 +/- 11.7 mg/kg/hr (0.49 +/- 0.20 mg/kg/min), respectively. The duration of propofol anesthesia was 45.3 +/- 13.2 minutes and recovery to standing occurred in 14.7 +/- 5.7 minutes. Sheep receiving xylazine-ketamine-halothane were anesthetized for 35.9 +/- 4.0 minutes and recovery to standing occurred within 28.5 +/- 7.5 minutes. Sheep anesthetized with propofol had a significantly higher heart rate, diastolic blood pressure and Pvo2, and a lower Pvco2 at 30 minutes and lower BE at 15 and 30 minutes than sheep anesthetized with xylazine-ketamine-halothane.
Propofol anesthesia was characterized by a smooth induction, effective surgical anesthesia and rapid recovery which was comparable to anesthesia with xylazine-ketamine-halothane.
Propofol may be indicated in situations when it is desirable to maintain anesthesia with an intravenous infusion followed by a rapid recovery in healthy sheep.
本研究评估丙泊酚的临床实用性和麻醉效果，并将这些效果与赛拉嗪-氯胺酮-氟烷麻醉对绵羊的效果进行比较。
前瞻性、随机临床试验。
14只健康成年雄性绵羊。
绵羊被随机分配到两种不同的药物方案中：（1）静脉推注丙泊酚（3毫克/千克），随后持续静脉输注；（2）赛拉嗪（0.11毫克/千克，静脉注射）和氯胺酮（2.2毫克/千克，静脉注射）诱导，随后进行氟烷麻醉。麻醉期间监测心率、呼吸频率和动脉血压。采集静脉血样进行血气分析。还记录诱导和恢复的质量。
用于诱导和维持麻醉的丙泊酚平均剂量分别为6.63±2.06毫克/千克和29.3±11.7毫克/千克/小时（0.49±0.20毫克/千克/分钟）。丙泊酚麻醉持续时间为45.3±13.2分钟，恢复站立时间为14.7±5.7分钟。接受赛拉嗪-氯胺酮-氟烷麻醉 的绵羊麻醉时间为35.9±4.0分钟，恢复站立时间在28.5±7.5分钟内。与接受赛拉嗪-氯胺酮-氟烷麻醉的绵羊相比，丙泊酚麻醉的绵羊在30分钟时心率、舒张压和静脉血氧分压显著更高，静脉血二氧化碳分压更低，在15分钟和30分钟时碱剩余更低。
丙泊酚麻醉的特点是诱导平稳、手术麻醉有效且恢复迅速,与赛拉嗪-氯胺酮-氟烷麻醉相当。
在希望通过静脉输注维持麻醉并使健康绵羊快速恢复的情况下，丙泊酚可能适用。
