Johnston S A, Budsberg S C
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, USA.
Vet Clin North Am Small Anim Pract. 1997 Jul;27(4):841-62. doi: 10.1016/s0195-5616(97)50083-0.
Anti-inflammatory medications have long been prescribed for relief of the pain and discomfort associated with OA. This occurs despite the recognized side effects associated with use of NSAIDs and corticosteroids. Available evidence suggests that NSAIDs provide this relief through a combination of central and peripheral actions. Recent discovery of two isoforms of cyclooxygenase has increased our understanding of NSAID activity and may result in identification of drugs that potentially will have fewer side effects. A review of NSAIDs used in veterinary medicine indicates that relatively little is known regarding their role in treating OA, although controlled studies involving carprofen and etodolac have increased our knowledge of the efficacy of specific NSAIDs used for this purpose.
长期以来，抗炎药物一直被用于缓解与骨关节炎（OA）相关的疼痛和不适。尽管使用非甾体抗炎药（NSAIDs）和皮质类固醇会产生公认的副作用，但这种情况仍在发生。现有证据表明，NSAIDs通过中枢和外周作用的组合来提供这种缓解。最近发现的两种环氧化酶同工型增加了我们对NSAID活性的理解，并可能导致识别出潜在副作用较少的药物。对兽医学中使用的NSAIDs的综述表明，尽管涉及卡洛芬和依托度酸的对照研究增加了我们对用于此目的的特定NSAIDs疗效的了解，但关于它们在治疗OA中的作用仍知之甚少。
