Sochor J, Klimes J, Sedlácek J
Katedra farmaceutické chemie a kontroly léciv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Ceska Slov Farm. 1997 Apr;46(2):78-83.
The present paper surveys the published HPLC methods evaluating profens in biological materials and reports a HPLC method for the determination of ibuprofen in the samples of whole blood. For liquid-liquid extraction, ibuprofen was analyzed on the reverse phases Separon SGX C18 with the mobile phase methanol-water (pH 3.0) and detected at 222 nm. The elaborated method was employed in a pharmacokinetic study of ibuprofen on laboratory rabbits.
本文综述了已发表的评估生物材料中丙酸类药物的高效液相色谱法，并报告了一种测定全血样本中布洛芬的高效液相色谱法。对于液-液萃取，布洛芬在反相Separon SGX C18柱上进行分析，流动相为甲醇-水（pH 3.0），检测波长为222 nm。所阐述的方法用于布洛芬在实验兔身上的药代动力学研究。
