运动障碍样消化不良患者的幽门螺杆菌感染与难消化固体的胃排空

Helicobacter pylori infection and gastric emptying of indigestible solids in patients with dysmotility-like dyspepsia.

作者信息

Fock K M, Khoo T K, Chia K S, Sim C S

机构信息

Dept. of Medicine, Toa Payoh Hospital, Singapore.

出版信息

Scand J Gastroenterol. 1997 Jul;32(7):676-80. doi: 10.3109/00365529708996517.

DOI:10.3109/00365529708996517

PMID:9246707

Abstract

BACKGROUND

The role of Helicobacter pylori and gastric motility in dysmotility-like dyspepsia is unclear. The aim of this study was to determine whether delayed gastric emptying of indigestible solids and H. pylori infection are associated with dysmotility-like dyspepsia.

METHODS

Thirty-two healthy volunteers and 72 patients fulfilling the criteria of dysmotility-like dyspepsia received a gastric emptying test using radiopaque markers, and the H. pylori status was determined by histology.

RESULTS

Twenty-seven percent of volunteers were H. pylori-positive, compared with 32% in the dyspeptic groups (P = NS). Gastric emptying was significantly slower in dyspeptic patients than controls and in H. pylori-positive patients than H. pylori-negative patients. Subjects with gastroparesis have a higher chance of developing dysmotility-like dyspepsia (odds ratio (OR), 2.5) than subjects with normal gastric emptying. Subjects with H. pylori and gastroparesis have an increased likelihood of developing dysmotility-like dyspepsia (OR, 4.3) than if either factor were present alone.

CONCLUSION

Our data suggest that gastroparesis alone and gastroparesis and H. pylori infection are associated with dysmotility-like dyspepsia.

摘要

背景

幽门螺杆菌和胃动力在运动障碍样消化不良中的作用尚不清楚。本研究的目的是确定难消化固体的胃排空延迟和幽门螺杆菌感染是否与运动障碍样消化不良有关。

方法

32名健康志愿者和72名符合运动障碍样消化不良标准的患者接受了使用不透X线标志物的胃排空试验，并通过组织学确定幽门螺杆菌状态。

结果

27%的志愿者幽门螺杆菌呈阳性，而消化不良组为32%（P=无显著性差异）。消化不良患者的胃排空明显慢于对照组，幽门螺杆菌阳性患者的胃排空明显慢于幽门螺杆菌阴性患者。胃轻瘫患者发生运动障碍样消化不良的几率（比值比[OR]，2.5）高于胃排空正常的患者。与单独存在任何一个因素相比，同时患有幽门螺杆菌和胃轻瘫的患者发生运动障碍样消化不良的可能性增加（OR，4.3）。