Meining A, Stolte M, Hatz R, Lehn N, Miehlke S, Morgner A, Bayerdörffer E
Medical Department II, Klinikum Grosshadern, University of Munich, Germany.
Virchows Arch. 1997 Jul;431(1):11-5. doi: 10.1007/s004280050063.
Infection with Helicobacter pylori (H. pylori) causes gastritis, and may be associated with gastric and duodenal ulcers and also with such malignant diseases as MALT lymphoma and gastric carcinoma. In order to determine whether there are differences in the degree and distribution of gastritis, each patient with H. pylori gastritis only (n = 50) was matched for sex and age with four patients, one each with H. pylori-associated duodenal ulcer, gastric ulcer, gastric carcinoma or MALT lymphoma. From each patient, two biopsies were taken from the antrum and two from the corpus for histopathological examination of H. pylori gastritis. The median summed gastritis score decreases in the following order: antrum: gastric ulcer > duodenal ulcer > gastritis alone > carcinoma > MALT lymphoma, and corpus: gastric ulcer > carcinoma > MALT lymphoma > gastritis alone and duodenal ulcer. We conclude that the degree and distribution of H. pylori gastritis differs significantly among H. pylori-associated diseases. These differences may explain some of the underlying pathomechanisms associated with H. pylori infection.
幽门螺杆菌（H. pylori）感染可导致胃炎，还可能与胃和十二指肠溃疡以及诸如黏膜相关淋巴组织（MALT）淋巴瘤和胃癌等恶性疾病有关。为了确定胃炎的程度和分布是否存在差异，仅患有幽门螺杆菌性胃炎的每位患者（n = 50）按性别和年龄与四名患者进行匹配，这四名患者分别患有幽门螺杆菌相关的十二指肠溃疡、胃溃疡、胃癌或MALT淋巴瘤。从每位患者的胃窦取两块活检组织，从胃体取两块活检组织，用于幽门螺杆菌性胃炎的组织病理学检查。胃炎总分中位数按以下顺序降低：胃窦：胃溃疡＞十二指肠溃疡＞单纯胃炎＞癌＞MALT淋巴瘤，胃体：胃溃疡＞癌＞MALT淋巴瘤＞单纯胃炎和十二指肠溃疡。我们得出结论，幽门螺杆菌性胃炎的程度和分布在幽门螺杆菌相关疾病之间存在显著差异。这些差异可能解释了与幽门螺杆菌感染相关的一些潜在病理机制。
