Magnarelli L A, Anderson J F, Stafford K C, Dumler J S
Department of Entomology, The Connecticut Agricultural Experiment Station 06504, USA.
J Wildl Dis. 1997 Jul;33(3):466-73. doi: 10.7589/0090-3558-33.3.466.
Serum samples from Peromyscus leucopus (white-footed mouse), collected in Connecticut (USA) in 1983, 1985, and during 1990 to 1993, were analyzed by an enzyme-linked immunosorbent assay (ELISA) or indirect fluorescent antibody (IFA) staining methods for antibodies to Borrelia burgdorferi (strain 2591), Babesia microti, Ehrlichia chaffeensis (Arkansas strain), and Ehrlichia equi (MRK strain). Of the 294 serum samples tested, 160 (54%) contained immunoglobulins to one or more of these pathogens. There were antibodies to two or more etiologic agents in 77 (48%) of the seropositive mice. Although it was uncommon to detect coexisting antibodies to all four pathogens (n = 5 positive mice), E. chaffeensis-reactive antibodies or immunoglobulins to E. equi were present along with those produced to B. burgdorferi and B. microti in 24 other mice. These rodents carry antibodies to several tick-borne pathogens at numerous sites in Connecticut and may play a role in the epizootiology of ehrlichiosis as well as babesiosis and Lyme borreliosis.
1983年、1985年以及1990年至1993年期间在美国康涅狄格州采集的白足鼠血清样本，采用酶联免疫吸附测定（ELISA）或间接荧光抗体（IFA）染色方法，检测针对伯氏疏螺旋体（菌株2591）、微小巴贝斯虫、恰菲埃立克体（阿肯色菌株）和马埃立克体（MRK菌株）的抗体。在检测的294份血清样本中，160份（54%）含有针对一种或多种这些病原体的免疫球蛋白。77只（48%）血清阳性小鼠体内存在针对两种或更多病原体的抗体。虽然同时检测到针对所有四种病原体的抗体并不常见（有5只阳性小鼠），但在另外24只小鼠中，除了产生针对伯氏疏螺旋体和微小巴贝斯虫的抗体外，还存在针对恰菲埃立克体的反应性抗体或针对马埃立克体的免疫球蛋白。这些啮齿动物在康涅狄格州的多个地点携带针对多种蜱传病原体的抗体，可能在埃立克体病以及巴贝斯虫病和莱姆病的动物流行病学中发挥作用。
