Dix D J
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Cell Stress Chaperones. 1997 Jun;2(2):73-7. doi: 10.1379/1466-1268(1997)002<0073:heafdg>2.3.co;2.
The dramatic transformations in nuclear content and cellular organization that occur during gametogenesis require unique regulation and execution of the mitotic and meiotic cell cycle, apoptotic cell death, DNA recombination and repair, and cellular differentiation. These processes are accompanied by the constitutive and developmentally regulated expression of a number of hsp70 genes encoding 70 kDa heat shock proteins (Hsp70), including several hsp70s whose expression is unique to male germ cells. Examining the expression and function of Hsp70s in germ cells has provided significant insights into mechanisms of hsp70 gene regulation and Hsp70 protein function, as well as the developmental processes of gametogenesis.
配子发生过程中发生的细胞核内容物和细胞组织的显著变化，需要有丝分裂和减数分裂细胞周期、凋亡性细胞死亡、DNA重组与修复以及细胞分化的独特调控和执行。这些过程伴随着许多编码70 kDa热休克蛋白（Hsp70）的hsp70基因的组成型和发育调控表达，包括几种其表达为雄性生殖细胞所特有的hsp70。研究Hsp70在生殖细胞中的表达和功能，为深入了解hsp70基因调控机制、Hsp70蛋白功能以及配子发生的发育过程提供了重要线索。
