Kiesch N, Stene J J, Goens J, Vanhooteghem O, Song M
Department of Dermatology, CHU Saint-Pierre, HUDERF, Brussels, Belgium.
Dermatology. 1997;194(4):395-7. doi: 10.1159/000246159.
Seven children with severe, rapidly evolving alopecia areata (AA) were treated with pulse steroid therapy (PST). AA had been present for 3-44 weeks and involved more than 30% of the scalp. One patient had alopecia totalis. Intravenous methylprednisolone (5 mg/kg twice a day) was administered for 3 days. No serious side effects were noted. At the 12-month follow-up, complete regrowth had occurred in 5 patients (71%). The patient with alopecia totalis had no regrowth. PST appears to be a promising and safe treatment for extensive, recent-onset AA in children. No response is to be expected in alopecia totalis or long-standing AA.
7名患有严重、快速进展性斑秃（AA）的儿童接受了脉冲类固醇疗法（PST）治疗。斑秃已存在3 - 44周，累及头皮超过30%。1例患者为全秃。静脉注射甲泼尼龙（5 mg/kg，每日2次），持续3天。未观察到严重副作用。在12个月的随访中，5例患者（71%）完全再生毛发。全秃患者无毛发再生。PST似乎是治疗儿童广泛性、近期发病斑秃的一种有前景且安全的疗法。全秃或长期斑秃患者预计无反应。
