Schantz S P, Savage H E, Sacks P, Alfano R R
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Environ Health Perspect. 1997 Jun;105 Suppl 4(Suppl 4):941-4. doi: 10.1289/ehp.97105s4941.
Native cellular fluorescence (NCF) represents the innate capacity of tissues to absorb and emit light of specified wavelengths. Recent advances in optical engineering and computer technology have provided the, opportunity to measure NCF characteristics of various tissues in vivo. This report will briefly review the current status of NCF analysis of various neoplastic tissues. The status of investigations involving the upper aerodigestive tract will be discussed. Though initial results demonstrate that neoplastic tissues can be discriminated from normal mucosa by NCF analysis, the biologic basis of this difference remains uncertain. This report will also emphasize that the ability to screen for cancer in aerodigestive mucosa may be enhanced through the assessment of multiple emission and excitation wavelengths. The true nature of the cellular fluorophores responsible for these mucosal spectral characteristics should be more fully defined in coming years.
天然细胞荧光（NCF）代表组织吸收和发射特定波长光的固有能力。光学工程和计算机技术的最新进展为在体内测量各种组织的NCF特性提供了机会。本报告将简要回顾各种肿瘤组织的NCF分析现状。将讨论涉及上呼吸道消化道的研究状况。尽管初步结果表明通过NCF分析可以将肿瘤组织与正常黏膜区分开来，但这种差异的生物学基础仍不确定。本报告还将强调，通过评估多个发射和激发波长，可能会提高对上呼吸道消化道黏膜癌症的筛查能力。在未来几年中，应更全面地确定负责这些黏膜光谱特征的细胞荧光团的真实性质。
