Lam S, MacAulay C, Hung J, LeRiche J, Profio A E, Palcic B
Cancer Imaging, B.C. Cancer Research Center, Vancouver, Canada.
J Thorac Cardiovasc Surg. 1993 Jun;105(6):1035-40.
The performance of a novel bronchoscopic fluorescence imaging system was compared with conventional white light bronchoscopy with a data base of 328 biopsy-confirmed sites from 53 patients and 41 volunteers. The two methods were found to have the same specificity (94%); however, the sensitivity of the fluorescence system (72.5%) was found to be 50% greater than that of the white light bronchoscopy (48.4%) in detecting dysplasia and carcinoma in situ. The fluorescence system uses a nonlinear discriminant function combining the red and green image intensity values to form a pseudoimage that, when displayed on an RGB monitor, allows the detection and delineation of abnormal areas. In 15% of the patients with lung cancer, synchronous carcinoma in situ was found in addition to the large invasive cancer. Of the current smokers in this study, 40% had moderate dysplasia and 12% had severe dysplasia. For the ex-smokers 25% had moderate dysplasia, 6% had severe dysplasia, and 13% had carcinoma in situ. Fluorescence imaging may become an important adjunct to conventional bronchoscopic examination to improve our ability to diagnose and stage lung cancer more accurately.
将一种新型支气管镜荧光成像系统的性能与传统白光支气管镜进行了比较，该研究以53例患者和41名志愿者的328个活检确诊部位为数据库。发现这两种方法具有相同的特异性（94%）；然而，在检测发育异常和原位癌方面，荧光系统的灵敏度（72.5%）比白光支气管镜（48.4%）高50%。荧光系统使用一种非线性判别函数，将红色和绿色图像强度值相结合，形成一个伪图像，当在RGB监视器上显示时，可用于检测和勾勒异常区域。在15%的肺癌患者中，除了大的浸润性癌外，还发现了同步原位癌。在本研究的当前吸烟者中，40%有中度发育异常，12%有重度发育异常。对于既往吸烟者，25%有中度发育异常，6%有重度发育异常，13%有原位癌。荧光成像可能成为传统支气管镜检查的重要辅助手段，以提高我们更准确地诊断肺癌和进行分期的能力。
