Domingues R B, Lakeman F D, Pannuti C S, Fink M C, Tsanaclis A M
Department of Pathology, University of São Paulo, Brazil.
Scand J Infect Dis. 1997;29(3):229-31. doi: 10.3109/00365549709019033.
Four case of herpes encephalitis (HSVE) are described. The diagnosis was established by polymerase chain reaction (PCR) assay of cerebrospinal fluid (CSF). These reports illustrate different situations in the clinical management of this disease. PCR was considered useful in confirming the HSVE diagnosis in 3 atypical cases, and in the differentiation between virologic failure and postinfectious encephalitis in a patient with recurrence of symptoms. A case with typical HSVE clinical findings is also reported where PCR was negative and a temporal lobe lymphoma was diagnosed at autopsy. This last case is representative of the utility of PCR in the management of other diseases mimicking HSVE.
本文描述了4例疱疹性脑炎（HSVE）。通过脑脊液（CSF）的聚合酶链反应（PCR）检测确诊。这些报告说明了该疾病临床管理中的不同情况。在3例非典型病例中，PCR被认为有助于确诊HSVE，并且在一名症状复发的患者中有助于区分病毒学失败和感染后脑炎。还报告了1例具有典型HSVE临床表现的病例，其PCR检测结果为阴性，尸检时诊断为颞叶淋巴瘤。最后这个病例代表了PCR在管理其他模仿HSVE的疾病中的作用。
