Rosok B, Brinchmann J E, Voltersvik P, Olofsson J, Bostad L, Asjö B
Department of Microbiology and Immunology, Centre for Research in Virology, N-5020 Bergen, Norway.
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9332-6. doi: 10.1073/pnas.94.17.9332.
Correlates of virus load and characteristics of virus-producing cells in tonsillar tissue were investigated. Our results suggest that when less than 1:100 tonsillar CD4(+) T cells from individuals infected with HIV type-1 (HIV-1) contain replication competent provirus, the level of CD4(+) T cells in tonsils is comparable to that observed in uninfected individuals. Virus load at or above this level was associated with low CD4 cell numbers in tonsillar tissue. Only a few percent of all infected T cells in tonsillar tissue were active virus producers, with minor differences observed between individuals. Plasma viremia was found to correlate with infectious virus load in tonsillar tissue. With less than 1:1,000 of CD4 cells in lymphoid tissues being involved in active virus production, direct cytopathic effect by HIV-1 on infected CD4 cells is unlikely to fully explain the immunodeficiency seen in AIDS.
研究了扁桃体组织中病毒载量的相关因素以及产生病毒的细胞特征。我们的结果表明，当感染1型人类免疫缺陷病毒（HIV-1）个体的扁桃体CD4(+) T细胞中每100个细胞中少于1个含有具有复制能力的前病毒时，扁桃体中CD4(+) T细胞的水平与未感染个体中观察到的水平相当。该水平及以上的病毒载量与扁桃体组织中CD4细胞数量低有关。扁桃体组织中所有受感染的T细胞中只有百分之几是活跃的病毒产生者，个体之间观察到的差异较小。发现血浆病毒血症与扁桃体组织中的感染性病毒载量相关。由于淋巴组织中每1000个CD4细胞中参与活跃病毒产生的细胞少于1个，HIV-1对受感染CD4细胞的直接细胞病变效应不太可能完全解释艾滋病中所见的免疫缺陷。
