Verhaegh M E, Arends J W, Majoie I M, Hoekzema R, Neumann H A
Department of Dermatology, University Hospital Maastricht, The Netherlands.
Dermatol Surg. 1997 Aug;23(8):695-700. doi: 10.1111/j.1524-4725.1997.tb00392.x.
Trichoepithelioma (TE) and basal cell carcinoma (BCC) have many features in common both clinically and histologically. Despite these many similarities TE and BCC represent different biological entities.
Recently, bcl-2 and CD34 have been reported as reliable markers in distinguishing the two types of tumor. Transforming growth factor-beta (TGF-beta), a multifunctional regulator of both cell growth and differentiation, was evaluated in this study.
The immunohistochemical expression of TGF-beta was compared with the distribution patterns of bcl-2 and CD34 in five BCCs, five TEs, and seven borderline cases.
All five TEs showed a diffuse cytoplasmic staining of tumor cells for TGF-beta, whereas four of five BCCs were TGF-beta negative. Of the seven equivocal cases of TE/BCC, five tumors demonstrated TGF-beta positivity in combination with negative bcl-2 staining corresponding to TE. The remaining two cases demonstrated the opposite staining pattern, characteristic for BCC.
The TGF-beta staining pattern appears to be a helpful additional marker together with bcl-2 in differentiating between TE and BCC. The demonstrated staining differences may relate to the distinct origin and biological behavior of the two tumors and may therefore be of value in subsequent patient management.
毛发上皮瘤（TE）和基底细胞癌（BCC）在临床和组织学上有许多共同特征。尽管有这些诸多相似之处，但TE和BCC代表不同的生物学实体。
最近，bcl-2和CD34已被报道为区分这两种肿瘤的可靠标志物。本研究评估了转化生长因子-β（TGF-β），它是细胞生长和分化的多功能调节因子。
比较了5例BCC、5例TE和7例临界病例中TGF-β的免疫组化表达与bcl-2和CD34的分布模式。
所有5例TE的肿瘤细胞均显示TGF-β弥漫性胞质染色，而5例BCC中有4例TGF-β阴性。在7例TE/BCC的疑难病例中，5例肿瘤表现为TGF-β阳性，同时bcl-2染色阴性，符合TE。其余2例表现出相反的染色模式，为BCC的特征。
TGF-β染色模式似乎是一种有用的辅助标志物，与bcl-2一起可用于区分TE和BCC。所显示的染色差异可能与这两种肿瘤的不同起源和生物学行为有关，因此可能对后续患者管理有价值。
