Schmidt M H, Möcks P, Lay B, Eisert H G, Fojkar R, Fritz-Sigmund D, Marcus A, Musaeus B
Central Institute of Mental Health, Department of Child and Adolescent Psychiatry, Mannheim, Germany.
Eur Child Adolesc Psychiatry. 1997 Jun;6(2):88-95. doi: 10.1007/BF00566671.
A crossover 'placebo'-controlled, double-blind design was used to examine the effectiveness of an oligoantigenic diet in 49 children with hyperactive/disruptive behavior disorder. Effects of diet were compared with those yielded by stimulant medication (methylphenidate). The study was conducted in an inpatient unit at the Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim. Change in behavior was measured in standardized situations by trained raters, including behavior assessment when testing with CPT and PAT, during a free play situation, and at school. Twelve children (24%) showed significant behavioral improvement in two behavior ratings during diet relative to control diet conditions. Methylphenidate used in 36 children yielded more responders (44%) than diet. The amount of positive changes in behavior in those who received both treatments was about the same. Although only effective in a minority of children, dietary treatment cannot be neglected as a possible access to treating hyperactive/disruptive children and merits further investigation.
采用交叉“安慰剂”对照双盲设计，研究了低抗原饮食对49名患有多动/破坏性行为障碍儿童的有效性。将饮食的效果与兴奋剂药物（哌醋甲酯）的效果进行了比较。该研究在曼海姆中央精神卫生研究所儿童和青少年精神病科的一个住院部进行。由训练有素的评估人员在标准化情境中测量行为变化，包括在使用连续性能测试（CPT）和持续性操作测试（PAT）进行测试时、自由玩耍情境中和在学校时的行为评估。12名儿童（24%）在饮食期间的两项行为评分中相对于对照饮食条件显示出显著的行为改善。36名儿童使用哌醋甲酯产生的反应者（44%）比饮食更多。接受两种治疗的儿童行为的积极变化量大致相同。尽管饮食治疗仅对少数儿童有效，但作为治疗多动/破坏性行为儿童的一种可能途径，不能忽视饮食治疗，值得进一步研究。
