Munckhof W J, Olden D, Turnidge J D
Department of Infectious Diseases and Clinical Epidemiology, Monash Medical Centre, Melbourne, Victoria, Australia.
Antimicrob Agents Chemother. 1997 Aug;41(8):1735-7. doi: 10.1128/AAC.41.8.1735.
The postantibiotic effect (PAE) of imipenem against Escherichia coli was measured at a wide variety of drug concentrations and times of exposure. We observed that the area under the concentration-time curve of drug exposure (AUC), the product of time of exposure and concentration of drug, is a much better predictor of the duration of the PAE than either parameter alone. We also measured the PAE of imipenem against strains of gram-positive and gram-negative bacteria for which MICs varied widely. The E50, the AUC required to produce 50% of the maximum PAE, is correlated with the MIC and is independent of species. This may explain why the duration of the PAE differs for bacteria of the same species for which MICs are different.
在多种药物浓度和暴露时间下测定了亚胺培南对大肠杆菌的抗生素后效应（PAE）。我们观察到，药物暴露的浓度-时间曲线下面积（AUC），即暴露时间与药物浓度的乘积，比单独的任何一个参数都更能预测PAE的持续时间。我们还测定了亚胺培南对最低抑菌浓度（MIC）差异很大的革兰氏阳性菌和革兰氏阴性菌菌株的PAE。产生最大PAE的50%所需的AUC即E50，与MIC相关且与菌种无关。这可能解释了为什么同一菌种中MIC不同的细菌其PAE持续时间也不同。
