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In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles.特比萘芬与氟康唑及伊曲康唑联合应用对唑类药物敏感性降低的白色念珠菌分离株的体外活性。
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2
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本文引用的文献

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Quality control guidelines for National Committee for Clinical Laboratory Standards--recommended broth macrodilution testing of ketoconazole and itraconazole.美国国家临床实验室标准委员会质量控制指南——酮康唑和伊曲康唑肉汤稀释法药敏试验推荐标准
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2
Variation in fluconazole efficacy for Candida albicans strains sequentially isolated from oral cavities of patients with AIDS in an experimental murine candidiasis model.在实验性小鼠念珠菌病模型中，从艾滋病患者口腔中依次分离出的白色念珠菌菌株对氟康唑的疗效差异。
Antimicrob Agents Chemother. 1996 May;40(5):1317-20. doi: 10.1128/AAC.40.5.1317.
3
Multiple-dose pharmacokinetics and distribution in tissue of terbinafine and metabolites.特比萘芬及其代谢物的多剂量药代动力学和组织分布
Antimicrob Agents Chemother. 1995 Dec;39(12):2738-41. doi: 10.1128/AAC.39.12.2738.
4
Fluconazole-resistant Candida albicans after long-term suppressive therapy.长期抑制性治疗后对氟康唑耐药的白色念珠菌。
Arch Intern Med. 1993 May 10;153(9):1122-4.
5
Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS: documentation by in vitro susceptibility testing and DNA subtype analysis.艾滋病患者口腔念珠菌病治疗期间白色念珠菌对氟康唑的耐药性：通过体外药敏试验和DNA亚型分析进行记录
Clin Infect Dis. 1994 Feb;18(2):240-2. doi: 10.1093/clinids/18.2.240.
6
Turbidimetric and visual criteria for determining the in vitro activity of six antifungal agents against Candida spp. and Cryptococcus neoformans.用于确定六种抗真菌药物对念珠菌属和新型隐球菌体外活性的比浊法和目视标准。
Mycopathologia. 1993 Oct;124(1):19-25. doi: 10.1007/BF01103052.
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Fluconazole-resistant Candida albicans.氟康唑耐药白色念珠菌
Clin Infect Dis. 1993 Dec;17(6):1018-21. doi: 10.1093/clinids/17.6.1018.
8
Selection of candidate quality control isolates and tentative quality control ranges for in vitro susceptibility testing of yeast isolates by National Committee for Clinical Laboratory Standards proposed standard methods.美国国家临床实验室标准委员会提出的标准方法用于酵母分离株体外药敏试验的候选质量控制菌株的选择及暂定质量控制范围。
J Clin Microbiol. 1994 Jul;32(7):1650-3. doi: 10.1128/jcm.32.7.1650-1653.1994.
9
Comparative study of broth macrodilution and microdilution techniques for in vitro antifungal susceptibility testing of yeasts by using the National Committee for Clinical Laboratory Standards' proposed standard.采用美国国家临床实验室标准委员会提议的标准，对肉汤稀释法的常量稀释和微量稀释技术用于酵母体外抗真菌药敏试验进行比较研究。
J Clin Microbiol. 1994 Oct;32(10):2494-500. doi: 10.1128/jcm.32.10.2494-2500.1994.
10
DNA subtypes and fluconazole susceptibilities of Candida albicans isolates from the oral cavities of patients with AIDS.来自艾滋病患者口腔的白色念珠菌分离株的DNA亚型及氟康唑敏感性
Clin Infect Dis. 1995 Mar;20(3):634-40. doi: 10.1093/clinids/20.3.634.

特比萘芬与氟康唑及伊曲康唑联合应用对唑类药物敏感性降低的白色念珠菌分离株的体外活性。

In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles.

作者信息

Barchiesi F, Falconi Di Francesco L, Scalise G

机构信息

Institute of Infectious Diseases and Public Health of the University of Ancona, Italy.

出版信息

Antimicrob Agents Chemother. 1997 Aug;41(8):1812-4. doi: 10.1128/AAC.41.8.1812.

DOI:10.1128/AAC.41.8.1812
PMID:9257768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164012/
Abstract

A checkerboard microdilution method was applied to study the in vitro interaction of terbinafine with either fluconazole and itraconazole against 30 strains of Candida albicans. Synergy was observed in 40% of the terbinafine-fluconazole interactions and in 43% of the terbinafine-itraconazole interactions, while antagonism was not observed. Even when only additivity was achieved, the combinations still showed beneficial effects since at least twofold reductions in the MICs of both drugs were found in 100% of the terbinafine-fluconazole interactions and in 76% of the terbinafine-itraconazole interactions.

摘要

采用棋盘微量稀释法研究特比萘芬分别与氟康唑和伊曲康唑对30株白色念珠菌的体外相互作用。在40%的特比萘芬 - 氟康唑相互作用和43%的特比萘芬 - 伊曲康唑相互作用中观察到协同作用，未观察到拮抗作用。即使仅实现相加作用，这些联合用药仍显示出有益效果，因为在100%的特比萘芬 - 氟康唑相互作用和76%的特比萘芬 - 伊曲康唑相互作用中，两种药物的最低抑菌浓度（MIC）至少降低了两倍。