Palmer J S, Plzak L F, Cromie W J
Section of Urology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
J Urol. 1997 Sep;158(3 Pt 2):1138-40. doi: 10.1097/00005392-199709000-00113.
Our aim was to quantify objectively the degree of vascular insufficiency produced by twisting versus clamping the spermatic cord, and determine the contribution of the vasal vessels to these changes using the laser Doppler flowmeter.
Three groups of 12 male Sprague-Dawley rats each were studied. Group 1 underwent 720-degree torsion of the spermatic cord, group 2 underwent vascular clamping of the spermatic cord with 1 clamp, excluding the anatomically separate vasal vessels, and group 3 underwent vascular clamping of the entire spermatic cord and vasal vessels with 2 clamps. Blood flow and histological changes were determined.
Vascular clamping of the spermatic cord in groups 2 and 3 resulted in a significant decrease in testicular blood flow compared to 720-degree torsion (p < 0.05). These flow changes correlated with more severe and reproducible gross changes, and histological features of seminiferous tubule degeneration compared to spermatic cord twisting.
In the rat clamping the spermatic cord is a more severe and reproducible model of testicular torsion than 720-degree torsion. The contribution of the vasal vessels to the decrease in blood flow and resulting histological degeneration after testicular ischemia is negligible in the rat.
我们的目的是使用激光多普勒血流仪客观量化精索扭转与夹闭所导致的血管功能不全程度，并确定输精管血管对这些变化的影响。
对三组雄性Sprague-Dawley大鼠进行研究，每组12只。第1组进行精索720度扭转，第2组用1个夹子夹闭精索血管，但不包括解剖学上独立的输精管血管，第3组用2个夹子夹闭整个精索和输精管血管。测定血流和组织学变化。
与720度扭转相比，第2组和第3组精索血管夹闭导致睾丸血流显著减少（p<0.05）。与精索扭转相比，这些血流变化与更严重且可重复的大体变化以及生精小管变性的组织学特征相关。
在大鼠中，夹闭精索是比720度扭转更严重且可重复的睾丸扭转模型。在大鼠中，输精管血管对睾丸缺血后血流减少及由此导致的组织学变性的影响可忽略不计。
