Tanzi M, Bellelli E, Benaglia G, Cavatorta E, Merialdi A, Mordacci E, Ribero M L, Tagger A, Verrotti C, Volpicelli A
Institute of Hygiene, University of Parma, Italy.
Eur J Epidemiol. 1997 Jul;13(5):517-21. doi: 10.1023/a:1007374810981.
The prevalence of antibodies for one or more HCV antigens was 2.3% of 1,347 mothers at childbirth. Compared with the principal factors studied, the presence of antibodies was more frequent in women who were carriers of HIV infection (3/3), in those who had suffered liver diseases (5/37) or who had had transfusion (3/25). This was as opposed to women who did not have any risk factor (p < 0.001). The prevalence of HCV-RNA was 1.3%; in relation to the antibody state, such a condition was more frequent in subjects with antibodies for 3 or 4 antigens (about 80%) compared with those who were positive for 1 or 2 antigens. HCV-RNA of the same genotype as the mother (type 1; 1a) was also found in the funicular blood of 2 of the 18 babies born to mothers who were positive for HCV-RNA. In the course of the follow-up (from the 3rd to the 18th month) the viral RNA was not found in any of the babies, nor was it found in the 2 who were positive at birth. Even the antibodies gradually disappeared, although slowly. At the 10th month, 91% of the babies resulted as having no antibodies and at the 18th month none of the babies resulted as having antibodies. Breast-feeding also appeared to have no influence on the transmission of the infection; out of 18 viremic mothers indeed 12 (67%) breast-fed their babies.
在1347名分娩母亲中，一种或多种丙肝病毒（HCV）抗原抗体的流行率为2.3%。与所研究的主要因素相比，HIV感染携带者女性（3/3）、患有肝脏疾病的女性（5/37）或接受过输血的女性（3/25）中抗体的存在更为常见。这与没有任何危险因素的女性相反（p<0.001）。HCV-RNA的流行率为1.3%；就抗体状态而言，与1种或2种抗原呈阳性的受试者相比，3种或4种抗原呈抗体阳性的受试者中这种情况更为常见（约80%）。在HCV-RNA呈阳性的母亲所生的18名婴儿中，有2名婴儿的脐血中也发现了与母亲相同基因型（1型；1a型）的HCV-RNA。在随访过程中（从第3个月到第18个月），在任何婴儿中均未发现病毒RNA，出生时呈阳性的2名婴儿中也未发现。即使抗体逐渐消失，尽管速度缓慢。在第10个月时，91%的婴儿检测结果显示没有抗体，在第18个月时，没有婴儿检测结果显示有抗体。母乳喂养似乎对感染传播也没有影响；在18名病毒血症母亲中，确实有12名（67%）母乳喂养了她们的婴儿。
