Caille G, Lelorier J, Latour Y, Besner J G
J Pharm Sci. 1977 Oct;66(10):1383-5. doi: 10.1002/jps.2600661007.
A specific, sensitive, rapid, and reproducible analytical GLC method for lidocaine in human plasma, including pharmacokinetic parameters, is described. Aminopyrine is the internal standard. The method was used to study pharmacokinetics in four healthy volunteers following the administration of a lidocaine bolus at a dose of 1 mg/kg iv and in one patient with cardiac arrhythmias who had been given a 50-mg bolus followed by a prolonged intravenous infusion for 30 hr.
本文描述了一种用于测定人血浆中利多卡因的特异性、灵敏、快速且可重复的气相色谱分析方法，包括药代动力学参数。氨基比林作为内标。该方法用于研究四名健康志愿者静脉注射1mg/kg利多卡因大剂量后的药代动力学，以及一名心律失常患者静脉注射50mg大剂量后持续静脉输注30小时的药代动力学。
