Steele J A, Mirocha C J, Pathre S V
J Toxicol Environ Health. 1977 Sep;3(1-2):35-42. doi: 10.1080/15287397709529547.
Twenty products associated with the metabolism of zearalenone by Fusarium roseum were analyzed with respect to time and culture conditions. By statistical analysis a set of six metabolites possibly related to zearalenone were selected. These products were characterized by gas chromatography--mass spectrometry and other methods. The chemical structures of these six confirmed the statistical relationships, and evidence for the formation of these materials from zearalenone is presented. A suggested scheme of metabolism of zearalenone by F. roseum includes the formation of the two isomers of 8'-hydroxyzearalenone, 6',8'-dihydroxyzearalene, 6-(carboxypentyl)-beta-resorcyclic acid, and phenylacetic acid derivatives.
对20种与粉红镰孢菌代谢玉米赤霉烯酮相关的产物进行了时间和培养条件方面的分析。通过统计分析，挑选出一组可能与玉米赤霉烯酮相关的六种代谢物。这些产物通过气相色谱 - 质谱联用及其他方法进行了表征。这六种物质的化学结构证实了统计关系，并给出了由玉米赤霉烯酮形成这些物质的证据。粉红镰孢菌代谢玉米赤霉烯酮的推测代谢途径包括8'-羟基玉米赤霉烯酮的两种异构体、6',8'-二羟基玉米赤霉烯、6-(羧基戊基)-β-间苯二酚酸和苯乙酸衍生物的形成。
