Heslegrave R J, Awad A G, Voruganti L N
Department of Psychiatry, University of Toronto, Wellesley Central Hospital, Ontario, Canada.
J Psychiatry Neurosci. 1997 Jul;22(4):235-43.
The purpose of the present study was to examine the relationship between neurocognitive deficits and self-reported quality of life in order to examine whether neurocognitive impairment interferes with any aspects of quality of life for patients with schizophrenia. Forty-two outpatients with stable chronic schizophrenia were assessed for neurocognitive deficits using a computerized test battery, and all patients completed a version of the Sickness Impact Profile (SIP) to assess their quality of life across a variety of domains. The neurocognitive assessment tests revealed significant deficits compared with normal control subjects, particularly with respect to impaired iconic memory and frontal functioning. Patients reported that their quality of life was compromised. Despite the substantiation of marked neurocognitive deficits and reduced quality of life, correlations between neurocognitive deficits and quality of life were largely nonsignificant or very weak. Symptom expression, however, particularly with regard to general psychopathology on the Positive and Negative Syndrome Scale (PANSS), was significantly associated with quality of life. These results suggest that neurocognitive deficits in schizophrenia, while often profound, appear to have little direct impact on the patient's perceived quality of life.
本研究的目的是检验神经认知缺陷与自我报告的生活质量之间的关系，以考察神经认知损害是否会干扰精神分裂症患者生活质量的任何方面。使用一套计算机化测试组合对42例病情稳定的慢性精神分裂症门诊患者进行神经认知缺陷评估，所有患者均完成了一个版本的疾病影响量表（SIP），以评估其在各个领域的生活质量。与正常对照受试者相比，神经认知评估测试显示出明显的缺陷，尤其是在图像记忆受损和额叶功能方面。患者报告称他们的生活质量受到了损害。尽管证实存在明显的神经认知缺陷且生活质量下降，但神经认知缺陷与生活质量之间的相关性大多不显著或非常微弱。然而，症状表现，特别是在阳性和阴性症状量表（PANSS）上的一般精神病理学方面，与生活质量显著相关。这些结果表明，精神分裂症患者的神经认知缺陷虽然往往很严重，但似乎对患者感知到的生活质量几乎没有直接影响。
