Meyer K, Westbrook S, Schwaibold M, Hajric R, Peters K, Roskamm H
Herz-Zentrum, Bad Krozingen, Germany.
Am Heart J. 1997 Jul;134(1):20-6. doi: 10.1016/s0002-8703(97)70102-9.
Eleven men with severe chronic heart failure (peak cardiac index 4.0 +/- 0.2 L/m2/min), six on a heart transplantation waiting list, were prospectively assessed. To determine reproducibility of cardiopulmonary and hemodynamic variables for clinical purposes during ramp bicycle ergometry, the patients underwent two ramp bicycle ergometer tests (3 minutes unloaded, work rate increments of 12.5 W/min) with a 1-week interval between tests. Oxygen uptake (VO2) carbon dioxide production (VCO2), and ventilation were measured breath by breath, and calculations were performed to determine gas exchange ratio, oxygen pulse, ventilatory equivalents of oxygen and carbon dioxide, and end-tidal partial pressure for oxygen and carbon dioxide. Additionally, heart rate, blood pressure, and lactate levels were assessed. Measurements were performed at submaximum work rate levels of 25 W, 50 W, and 75 W at ventilatory threshold and at peak work rate. At all measurement points, the coefficient of variation for cardiopulmonary variables was between 1.4% and 7.1% for submaximum work rate levels, between 1.2% and 4.4% at ventilatory threshold, and between 2.4% and 7.1% at peak work rate. For heart rate, blood pressure, and lactate levels, coefficient of variation was between 2.7% and 5.7% for submaximum work rate levels, between 1.4% and 6.1% at ventilatory threshold, and between 1.2% and 5.5% at peak work rate. The data suggest high reproducibility for duplicate measurements of cardiopulmonary and hemodynamic variables during ramp bicycle ergometry in patients with severe chronic heart failure. The results may be used to determine whether any variable in a single patient is significantly different from that obtained in a previous exercise test or if the change is within experimental error.
对11名重度慢性心力衰竭男性患者（心脏指数峰值为4.0±0.2L/m²/min）进行了前瞻性评估，其中6人在心脏移植等候名单上。为了确定在斜坡式自行车测力计运动期间心肺和血流动力学变量用于临床目的的可重复性，患者进行了两次斜坡式自行车测力计测试（3分钟无负荷，工作速率以12.5W/min递增），两次测试间隔1周。逐次测量摄氧量（VO₂）、二氧化碳生成量（VCO₂）和通气量，并进行计算以确定气体交换率、氧脉搏、氧和二氧化碳的通气当量以及氧和二氧化碳的呼气末分压。此外，还评估了心率、血压和乳酸水平。在通气阈值和峰值工作速率下，在25W、50W和75W的次最大工作速率水平进行测量。在所有测量点，次最大工作速率水平下心肺变量的变异系数在1.4%至7.1%之间，通气阈值时在1.2%至4.4%之间，峰值工作速率时在2.4%至7.1%之间。对于心率、血压和乳酸水平，次最大工作速率水平下变异系数在2.7%至5.7%之间，通气阈值时在1.4%至6.1%之间，峰值工作速率时在1.2%至5.
