Lee C, Wevrick R, Fisher R B, Ferguson-Smith M A, Lin C C
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Hum Genet. 1997 Sep;100(3-4):291-304. doi: 10.1007/s004390050508.
Human centromeres have been extensively studied over the past two decades. Consequently, more is known of centromere structure and organization in humans than in any other higher eukaryote species. Recent advances in the construction of a human (or mammalian) artificial chromosome have fostered increased interest in determining the structure and function of fully functional human centromeres. Here, we present an overview of currently identified human centromeric repetitive DNA families: their discoveries, molecular characterization, and organization with respect to other centromeric repetitive DNA families. A brief examination of some functional based studies is also included.
在过去二十年里，人类着丝粒得到了广泛研究。因此，相较于其他任何高等真核生物物种，我们对人类着丝粒的结构和组织了解得更多。人类（或哺乳动物）人工染色体构建方面的最新进展激发了人们对确定全功能人类着丝粒的结构和功能的更大兴趣。在这里，我们概述了目前已鉴定出的人类着丝粒重复DNA家族：它们的发现、分子特征以及与其他着丝粒重复DNA家族的组织关系。还包括对一些基于功能的研究的简要考察。
