年龄相关性黄斑变性患者脉络膜新生血管膜手术切除后脉络膜毛细血管灌注减少。
Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration.
作者信息
Nasir M A, Sugino I, Zarbin M A
机构信息
Department of Ophthalmology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey 07103-2499, USA.
出版信息
Br J Ophthalmol. 1997 Jun;81(6):481-9. doi: 10.1136/bjo.81.6.481.
AIMS/BACKGROUND: To evaluate macular changes following surgical excision of subfoveal choroidal neovascular membranes (CNVs) in age-related macular degeneration (AMD).
METHODS
The clinical records, fluorescein angiograms, and CNV histopathology of 12 patients with AMD who underwent surgical excision of subfoveal CNV were reviewed.
RESULTS
New areas of decreased choriocapillaris perfusion were noted by fluorescein angiography in the previous location of the CNV in 8/12 (75%) cases. Surgically excised tissue contained retinal pigment epithelium (RPE) in 11/11 specimens and choriocapillaris in 1/11 specimen studied.
CONCLUSIONS
Choriocapillaris atrophy may partly underlie the limited visual outcome following subfoveal surgery for AMD. Abnormal choriocapillaris perfusion following CNV excision may be due to pre-existing choriocapillaris atrophy, to choriocapillaris damage or removal at the time of surgery, or to RPE removal at surgery with abnormal RPE repopulation of the dissected area and subsequent choriocapillaris degeneration.
目的/背景：评估年龄相关性黄斑变性（AMD）患者视网膜下脉络膜新生血管膜（CNV）手术切除后黄斑的变化。
方法
回顾了12例行视网膜下CNV手术切除的AMD患者的临床记录、荧光素血管造影和CNV组织病理学检查结果。
结果
荧光素血管造影显示，8/12（75%）的病例在先前CNV所在部位出现了新的脉络膜毛细血管灌注降低区域。在研究的11个手术切除标本中，11个含有视网膜色素上皮（RPE），1个含有脉络膜毛细血管。
结论
脉络膜毛细血管萎缩可能是AMD患者视网膜下手术视觉效果有限的部分原因。CNV切除后脉络膜毛细血管灌注异常可能是由于术前存在的脉络膜毛细血管萎缩、手术时脉络膜毛细血管损伤或切除，或手术时RPE切除，随后解剖区域RPE异常重新填充以及脉络膜毛细血管变性所致。
Zotero 插件