Krautschick A, Esen T
Department of Urology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
World J Urol. 1997;15(4):213-8. doi: 10.1007/BF01367658.
The complex and multifactorial phenomenon of urinary stone disease remains unclear. Anatomical and physiochemical theories do not adequately deal with certain aspects of idiopathic calcium oxalate nephrolithiasis in particular or of nephrolithiasis. One of the reasons for this could be that nephrolithiasis is not only a primary disorder but may also be a symptom of other disorders or various pathologic changes in the metabolism of lithogenic substances. Both affirmative and contradictory reports have been published since Randall's first description of papillary calcifications and their possible active role in the genesis of calcium oxalate nephrolithiasis. Our intention is to discuss focal calcified lesions as an etiologic factor of renal stone disease as well as the change from historical to modern concepts regarding the development of medullary calcifications and their relationship to idiopathic calcium oxalate nephrolithiasis.
尿路结石病这种复杂的多因素现象仍不清楚。解剖学和物理化学理论无法充分解释特发性草酸钙肾结石或肾结石的某些方面。造成这种情况的原因之一可能是，肾结石不仅是一种原发性疾病，还可能是其他疾病的症状，或者是致石物质代谢中各种病理变化的表现。自从兰德尔首次描述乳头钙化及其在草酸钙肾结石形成中可能的积极作用以来，既有肯定的报告，也有相互矛盾的报告。我们的目的是讨论局灶性钙化病变作为肾结石病的病因，以及从历史概念到现代概念关于髓质钙化的发展及其与特发性草酸钙肾结石的关系的转变。
