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单线态氧是体外培养的人皮肤成纤维细胞中细胞因子依赖性紫外线A诱导间质胶原酶产生过程中的早期中间体。

Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro.

作者信息

Wlaschek M, Wenk J, Brenneisen P, Briviba K, Schwarz A, Sies H, Scharffetter-Kochanek K

机构信息

Department of Dermatology, University of Cologne, Germany.

出版信息

FEBS Lett. 1997 Aug 18;413(2):239-42. doi: 10.1016/s0014-5793(97)00919-8.

Abstract

Ultraviolet (UV) A irradiation of human dermal fibroblasts elicits an increase in specific mRNA amounts and bioactivities of the cytokines IL-1alpha, IL-1beta, and IL-6. These effects are enhanced in deuterium oxide-based medium and are diminished in the presence of non-toxic concentrations of sodium azide. Furthermore, generating singlet oxygen outside the cells by irradiation of rose bengal-coated resin particles with visible light (lambda > 450 nm) results in the induction of interstitial collagenase, IL-1 and IL-6, similar to the response observed with UVA irradiation. These observations suggest that singlet oxygen is an early intermediate in the signaling pathway of IL-1 and IL-6 mediating UVA induction of interstitial collagenase (E.C. 3.4.24.7). Furthermore, singlet oxygen appears to initiate this complex UV response at the cell membrane.

摘要

紫外线A(UVA)照射人皮肤成纤维细胞会引发细胞因子IL-1α、IL-1β和IL-6的特定mRNA量及生物活性增加。在基于重水的培养基中这些效应会增强,而在无毒浓度的叠氮化钠存在时则会减弱。此外,通过用可见光(波长>450 nm)照射孟加拉玫瑰红包被的树脂颗粒在细胞外产生单线态氧,会导致间质胶原酶、IL-1和IL-6的诱导,这与UVA照射所观察到的反应相似。这些观察结果表明单线态氧是介导UVA诱导间质胶原酶(E.C. 3.4.24.7)的IL-1和IL-6信号通路中的早期中间体。此外,单线态氧似乎在细胞膜处引发这种复杂的紫外线反应。

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