[麻风病患者细胞因子产生的评估]
[Evaluation of cytokine production in leprosy patients].
作者信息
Fink S, Finiasz M R, Valdez R, de la Barrera S, Sasiain M C
机构信息
Departamento Inmunología, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
出版信息
Medicina (B Aires). 1996;56(6):705-8.
The aim of the present study was to evaluate the cytokine production by peripheral blood mononuclear cells (PBMC) of leprosy patients when the cells were stimulated in culture by ConA, PPD or M.leprae. We measured IL-2, IL-4, IFN-gamma and IL-6 in cell-free supernatants by enzyme linked immunoassays. Our results do not suggest a clear association of a clinical form of leprosy with either Th1 or Th2 cytokine secretion profile in PBMC of leprosy patients.
本研究的目的是评估麻风病人外周血单个核细胞（PBMC）在体外被刀豆蛋白A（ConA）、结核菌素纯蛋白衍生物（PPD）或麻风杆菌刺激后细胞因子的产生情况。我们通过酶联免疫吸附测定法测量无细胞上清液中的白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、γ-干扰素（IFN-γ）和白细胞介素-6（IL-6）。我们的结果并未表明麻风病的临床类型与麻风病人PBMC中Th1或Th2细胞因子分泌模式存在明确关联。
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