Nieman D C, Henson D A, Butterworth D E, Warren B J, Davis J M, Fagoaga O R, Nehlsen-Cannarella S L
Department of Health, Appalachian State University, Boone, NC 28608, USA.
Int J Sport Nutr. 1997 Sep;7(3):173-84. doi: 10.1123/ijsn.7.3.173.
This randomized, double-blind, placebo-controlled study was designed to determine the influence of vitamin C supplementation on the immune response to 2.5 hr of high-intensity running. Twelve experienced marathon runners (VO2 max 51.6 +/- 1.5 ml.kg-1.min-1, age 40.5 +/- 2.0 years) were randomized into vitamin C (1,000 mg/day for 8 days) or placebo groups. On the test day, subjects ran at 75-80% VO2 max for 2.5 hr, with five blood samples taken before and for 6 hr after. Blood samples were analyzed for cortisol and catecholamines; leukocyte subsets; interleukin-6; natural killer cell activity; lymphocyte proliferation as induced by concanavalin A, phytohemagglutinin, and pokeweed mitogen; and granulocyte phagocytosis and activated oxidative burst. Compared with placebo, vitamin C supplementation had no significant effect on the pattern of change in any of these hormonal or immune measures following 2.5 hr of intensive running.
这项随机、双盲、安慰剂对照研究旨在确定补充维生素C对高强度跑步2.5小时后免疫反应的影响。12名经验丰富的马拉松运动员（最大摄氧量51.6±1.5毫升·千克⁻¹·分钟⁻¹，年龄40.5±2.0岁）被随机分为维生素C组（每天1000毫克，共8天）或安慰剂组。在测试当天，受试者以最大摄氧量的75%-80%跑步2.5小时，在跑步前和跑步后6小时采集五份血样。对血样进行皮质醇和儿茶酚胺、白细胞亚群、白细胞介素-6、自然杀伤细胞活性、伴刀豆球蛋白A、植物血凝素和商陆有丝分裂原诱导的淋巴细胞增殖以及粒细胞吞噬作用和活性氧化爆发的分析。与安慰剂相比，补充维生素C对高强度跑步2.5小时后这些激素或免疫指标的变化模式没有显著影响。
