Nieman D C, Henson D A, Garner E B, Butterworth D E, Warren B J, Utter A, Davis J M, Fagoaga O R, Nehlsen-Cannarella S L
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA.
Med Sci Sports Exerc. 1997 Oct;29(10):1318-24. doi: 10.1097/00005768-199710000-00007.
This randomized, double-blind, placebo-controlled study was designed to determine the influence of carbohydrate supplementation on the natural killer cell response to 2.5 h of high-intensity running (76.7 +/- 0.4% VO2max). Thirty experienced marathon runners (VO2max 53.4 +/- 1.0 mL x kg[-1] x min[-1], age 41.5 +/- 1.4 yr) were randomized into carbohydrate supplement (N = 17) and placebo (N = 13) groups. Subjects rested for 10-15 min before a blood sample at 0715, and then ingested 0.75 L of carbohydrate beverage (Gatorade) or placebo. At 0730, subjects began running at 75-80% VO2max for 2.5 h and drank 0.25 L of carbohydrate or placebo fluid every 15 min. Immediately after the 2.5 h run (1000), another blood sample was taken, followed by 1.5 h, 3 h, and 6-h recovery samples. Carbohydrate supplementation versus placebo had a significant effect on the pattern of change in glucose, cortisol, and the blood concentration of natural killer cells ([F (4,25) = 3.79, P = 0.015], but not natural killer cell activity following 2.5 h of intensive running.
这项随机、双盲、安慰剂对照研究旨在确定碳水化合物补充对自然杀伤细胞对2.5小时高强度跑步（76.7±0.4%最大摄氧量）反应的影响。30名经验丰富的马拉松运动员（最大摄氧量53.4±1.0 mL·kg⁻¹·min⁻¹，年龄41.5±1.4岁）被随机分为碳水化合物补充组（N = 17）和安慰剂组（N = 13）。受试者在0715采集血样前休息10 - 15分钟，然后摄入0.75 L碳水化合物饮料（佳得乐）或安慰剂。0730时，受试者开始以75 - 80%最大摄氧量跑步2.5小时，每15分钟饮用0.25 L碳水化合物或安慰剂饮料。在2.5小时跑步结束后立即（1000时）采集另一份血样，随后在1.5小时、3小时和6小时恢复时采集血样。碳水化合物补充与安慰剂相比，对葡萄糖、皮质醇和自然杀伤细胞血浓度的变化模式有显著影响（[F(4,25)=3.79，P = 0.015]），但对2.5小时高强度跑步后的自然杀伤细胞活性没有影响。
