人乳头瘤病毒在外眼的肿瘤性和非肿瘤性病变中的情况。
Human papilloma virus in neoplastic and non-neoplastic conditions of the external eye.
作者信息
Karcioglu Z A, Issa T M
机构信息
King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
出版信息
Br J Ophthalmol. 1997 Jul;81(7):595-8. doi: 10.1136/bjo.81.7.595.
AIM
Human papilloma virus (HPV) types 16 and 18 have been associated with neoplastic conditions of the conjuctiva. However, the presence of this virus has not been reported in non-neoplastic disorders of the external eye nor has it been studied in normal conjunctival tissues.
METHODS
Ninety six paraffin embedded tissue specimens with neoplastic and non-neoplastic lesions and 19 conjunctiva samples free from overt disease were studied for HPV types 16 and 18 positivity with the polymerase chain reaction.
RESULTS
HPV types 16 and 18 DNA were identified in 57% of in situ squamous cell carcinoma, in 55% of invasive squamous cell carcinoma, in 20% of climatic droplet keratopathy, in 35% of scarred corneas, and in 32% of normal conjunctival tissue obtained during routine cataract extractions.
CONCLUSION
These findings indicate that HPV types 16 and 18 are detectable with the polymerase chain reaction not only in epithelial neoplasms of the ocular mucous membrane but also in non-neoplastic lesions as well as in apparently healthy conjunctiva.
目的
人乳头瘤病毒（HPV）16型和18型与结膜的肿瘤性疾病相关。然而，尚未有该病毒在外眼非肿瘤性疾病中的存在情况的报道，也未在正常结膜组织中进行过研究。
方法
采用聚合酶链反应研究了96例有肿瘤性和非肿瘤性病变的石蜡包埋组织标本以及19例无明显疾病的结膜样本中的HPV 16型和18型阳性情况。
结果
在57%的原位鳞状细胞癌、55%的浸润性鳞状细胞癌、20%的气候性小滴状角膜病变、35%的瘢痕化角膜以及32%的常规白内障摘除术中获取的正常结膜组织中检测到了HPV 16型和18型DNA。
结论
这些发现表明，采用聚合酶链反应不仅可在眼黏膜上皮肿瘤中检测到HPV 16型和18型，在非肿瘤性病变以及看似健康的结膜中也可检测到。
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