Palanker D, Turovets I, Lewis A
Laser Center, Hadassah Medical Organization and NanoMed, Jerusalem, Israel.
Lasers Surg Med. 1997;21(3):294-300. doi: 10.1002/(sici)1096-9101(1997)21:3<294::aid-lsm10>3.0.co;2-d.
Cavitation bubbles have been shown to be the driving force of tissue cutting in 193 nm ArF excimer laser-based vitreoretinal microsurgery. In the present work we investigate the dynamics of cavitation bubbles inside a gelatin gel in a saline environment using fast flash microphotography.
STUDY DESIGN/MATERIALS AND METHODS: The screening influence of the saline medium was found to restrict the maximal distance between the tip and the tissue at which cavitation bubbles are created to < 100 microns at an energy fluence up to 0.3 J/cm2/pulse (the maximal energy fluence applied in vitreoretinal surgery).
Single laser pulses did not cause disruption of gelatin at an energy fluence of up to 0.4 J/cm2/pulse. During the application of repetitive pulses small insoluble gas-containing bubbles were produced and often trapped between the tip and the tissue. They completely changed the shape of the subsequent cavitation bubbles and caused deep crater formation in the gel.
在基于193nm氩氟准分子激光的玻璃体视网膜显微手术中，空化气泡已被证明是组织切割的驱动力。在本研究中，我们使用快速闪光显微摄影技术研究了盐水环境中明胶凝胶内空化气泡的动力学。
研究设计/材料与方法：发现盐水介质的筛选作用将产生空化气泡的尖端与组织之间的最大距离限制在能量通量高达0.3J/cm²/脉冲（玻璃体视网膜手术中应用的最大能量通量）时小于100微米。
在能量通量高达0.4J/cm²/脉冲时，单个激光脉冲不会导致明胶破裂。在重复脉冲作用期间，会产生小的含不溶性气体的气泡，并且这些气泡常常被困在尖端与组织之间。它们完全改变了随后空化气泡的形状，并在凝胶中导致深凹坑形成。
