Hales B J, Thomas W R
Division of Molecular Biology, TVW Thelethon Institute for Child Health Research, Perth, Australia.
Clin Exp Allergy. 1997 Aug;27(8):868-75.
Dermatophagoides pteronyssinus and Euroglyphus maynei frequently occur in house dust but little is known about primary sensitization to the less abundant E. maynei.
To determine the occurrence of primary sensitization to E. maynei by T-cell responses and the crossreactivity to D. pteronyssinus.
The proliferative response of peripheral blood cells to overlapping peptides from Der p 1 and Eur m 1 were measured as well as to peptides from Der f 1, an allergen not found in the study environment.
The most frequent and strongest responses were to Der p 1 peptides especially in the region 105-133. However, 3/17 responders to mite peptides were stimulated predominantly by Eur m 1 peptides and a further two had their highest response to an Eur m 1 peptide. There was very little crossreactivity between Der p 1 and Eur m 1 peptides and very little response to peptides from Der f 1.
E. maynei group 1 allergens are a significant source of primary T-cell sensitization and have little T-cell crossreactivity with D. pteronyssinus or D. farinae.
屋尘中经常出现粉尘螨和梅氏嗜霉螨，但对于对含量较少的梅氏嗜霉螨的初次致敏情况了解甚少。
通过T细胞反应确定对梅氏嗜霉螨的初次致敏情况以及与粉尘螨的交叉反应性。
检测外周血细胞对来自Der p 1和Eur m 1的重叠肽段的增殖反应，以及对来自Der f 1（研究环境中未发现的一种变应原）的肽段的增殖反应。
最常见且最强的反应是针对Der p 1肽段，尤其是在105 - 133区域。然而，17名对螨肽有反应者中有3名主要受到Eur m 1肽段的刺激，另外两名对Eur m 1肽段反应最高。Der p 1和Eur m 1肽段之间的交叉反应性非常低，对Der f 1肽段的反应也非常少。
梅氏嗜霉螨1类变应原是初次T细胞致敏的重要来源，与粉尘螨或粗脚粉螨几乎没有T细胞交叉反应性。
