Bode U, Wonigeit K, Pabst R, Westermann J
Center of Anatomy, Medical School of Hannover, Germany.
Eur J Immunol. 1997 Aug;27(8):2087-93. doi: 10.1002/eji.1830270837.
After activation within a lymphoid tissue, T lymphocytes enter the blood, where they circulate and then re-enter many organs. However, they predominantly end up in the tissue of origin, a phenomenon so far thought to be caused by organ-specific homing. We analyzed the fate of T cells from different sources stimulated via the T cell receptor and CD28 and then injected intravenously into rats. Our results showed that preferential proliferation and reduced apoptosis, rather than preferential immigration, were responsible for the accumulation of activated T cells in the tissue of origin, explaining how immune responses can spread from site to site but still be restricted to certain regions. Manipulating the life span of such cells might be a promising approach to influencing immune responses.
在淋巴组织内被激活后，T淋巴细胞进入血液，在血液中循环，然后再次进入许多器官。然而，它们主要最终会回到起源组织，这一现象迄今为止被认为是由器官特异性归巢引起的。我们分析了来自不同来源的T细胞的命运，这些T细胞通过T细胞受体和CD28被激活，然后静脉注射到大鼠体内。我们的结果表明，激活的T细胞在起源组织中的积累是由优先增殖和凋亡减少导致的，而非优先迁移，这解释了免疫反应如何能从一个部位扩散到另一个部位，但仍局限于某些区域。操纵这些细胞的寿命可能是影响免疫反应的一种有前景的方法。
